Wynik wyszukiwania w bazie Polska Bibliografia Lekarska GBL

Zapytanie: ZOLICH
Liczba odnalezionych rekordów: 2

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Tytuł oryginału: Hepatocyte growth factor levels in liver and blood, and post-operative liver cell proliferation in patients with benign and malignant liver tumors after partial hepatectomy.
Autorzy: Dłużniewska Joanna, Zolich Dorota, Polański Jerzy, Zając Leszek, Sitkiewicz Dariusz, Łukomska Barbara
Źródło: Med. Sci. Monitor 2002: 8 (10) s.CR690-CR696, il., tab., bibliogr. 35 poz.
Sygnatura GBL: 313,278

Hasła klasyfikacyjne GBL:
  • chirurgia
  • gastroenterologia
  • onkologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.

    Streszczenie angielskie: Background: The purpose of our study was to investigate hepatocyte proliferation and the expression of hepatocyte growth factor (HGF) in liver tissue and blood from patients with benign and malignant liver tumors after partial hepatectomy. Material/Methods: We studied 25 consecutive patients undergoing partial hepatectomy for metastatic colorectal adenocarcinoma (15 cases) adn benign liver tumors (10 cases). Immunohistochemical examination for teh rpesence of PCNA adn HGF, c-Met/HGF-receptor expression was performed on formalin-fixed samples from: a) sections of resected fragments of liver tissue remote from the tumor; b) tumor tissue; c) remnant liver, 30 min after hepatectomy; d) fine needle aspiration liver biopsy, 7 days after liver resection. Circulating HGF and the level fo AFP adn GGT as biomarkers for liver cell regeneration were measured in the patients' blood at the same time. Results: The proliferation rate of liver cells was higher in patients with malignant than benign liver tumors. This correlated with incrased HGF in blood, but not with the expression of HGF and c-MET/HGF-R in liver tissue. The expression of HGF was detected in specimens from colorectal liver metastases. Conclusion: The mutual interactions between tumor and other cells may influence the proliferation of hepatocytes throughout the regenerative process in patients with colorectal carcinoma metastases after partial hepatectomy.


    Tytuł oryginału: Differentiation of cellular reaction to alloantigens and bacterial infection in human skin graft - immunosuppressive drugs or antibiotics.
    Autorzy: Mościcka-Wesołowska M., Olszewski W. L., Zolich D., Stelmach E.
    Źródło: Ann. Transplant. 2002: 7 (4) s.25-27, il., tab., bibliogr. 5 poz.
    Sygnatura GBL: 313,259

    Hasła klasyfikacyjne GBL:
  • immunologia
  • transplantologia
  • dermatologia i wenerologia
  • mikrobiologia

    Typ dokumentu:
  • praca związana ze zjazdem
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • zwierzęta
  • myszy
  • in vitro

    Streszczenie angielskie: The human hand transplantations prompted revival of interest in evaluation of the rejection process of the grafted skin and its control with the antirejection drugs [1-3]. In case of first hand transplantation a combined immunsuppressive regimen was applied with currently available drugs resulting in acceptance of the entire composite graft. No major untoward systemic effects of antirejection therapy were observed. The most important clinical conclusion was the allogenic skincan be accepted and function as in a normal extremity, altough the attack of host cells on the graft can not be totally eliminated. Chronic perivascular and subepidermal infiltrates with recipient cells could be seen [4]. Another problem connected with skin transplantion is graft infection. Skin is inhabited by a specific spectrum of bacteria [5]. Allografted skin is more sensitive to bacterial penetration that normal skin due to local damage by the host-versus-graft cellular reaction and comprised immune reactivity to bacterial antigens by the immunosuppressive therapy. The histological pictures of rejecting skin represent a mixture of cellular reaction against the graft and penetrating microbes. Alloreaction requires modification of immunosuppressive regimen and infection is an indication for prolonged antibiotic therapy against skin bacteria flora. The question arises how to discriminate the alloreactive and bacterial changes in the skin graft. We studied the histological pictures of rejecting and infected human skin after transplantation to scid mice.

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