Wynik wyszukiwania w bazie Polska Bibliografia Lekarska GBL

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Liczba odnalezionych rekordów: 3



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Tytuł oryginału: Soluble cytokine receptors in renal vasculitis and lupus nephritis.
Autorzy: Tesar Vladimir, Jirsa jr Milan, Zima Tomas, Kalousova Marta, Bartunkova Jirina, Stejskalova Alena, Dostal Ctibor, Zabka Jiri
Źródło: Med. Sci. Monitor 2002: 8 (1) s.BR24-BR29, tab., bibliogr. 49 poz.
Sygnatura GBL: 313,278

Hasła klasyfikacyjne GBL:
  • immunologia
  • nefrologia

    Typ dokumentu:
  • praca kliniczna
  • badanie porównawcze
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.

    Streszczenie angielskie: Background: The activation of various cytokines, e.g. TNFŕ, IL-1 and/or IL-6, may play an important role in the pathogenesis of renal vasculitis and lupus nephritis (LN). The systemic effect of these cytokines may be modulated by their circulating soluble receptors. The plasma levels of cytokine receptors may thus also be markers of the activation of these cytokines. Material/Methods: The plasma levels of TNFŕ, its soluble receptor p75 (sTNF-RII), IL-6, and the soluble IL-6 receptor (sIL-6R) were measured using ELISA in 17 patients with ANCA-positive renal vasculitis (12 active - ANCA-A, 7 in remission ANCA-R), 9 patients with active lupus nephritis (LN), and 5 healthy subjects. Results: Patients with LN had increased plasma levels of TNFŕ, sTNF-RII, IL-6 and sIL-6R in comparison with controls. Patients with ANCA-A also had increased plasma levels of TNFŕ, sTNF-RII adn sIL-6R in comparison with controls, but the increases in the plasma level of IL-6 was not statistically significant, due to the large standard deviation. Patients with ANCA-R had increased plasma levels of sTNF-RII in comparison to controls, but the plasma levels of TNFŕ were significantly lower in ANCA-R than in NANCA-A. While the ratio of TNFŕ to sTNF-RII was significantly lower in all groups of patients than in the acontrols, the ratio of IL-6 to sIL-6R was significantly increased only in LN in comparison to controls. Conclusions: While increased plasma levels of TNFŕ may be a nonspecific marker of the activity of ANCA-positive renal vasculitis and LN...

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    Tytuł oryginału: Influence of losartan and enalapril on urinary excretion of 8-isoprostane in experimental nephrotic syndrome.
    Autorzy: Tesar Vladimir, Zima Tomas, Jirsa jr Milan, Crkovska Jirina, Stipek Stanislav, Vernerova Zdena, Serakova Marketa
    Źródło: Med. Sci. Monitor 2002: 8 (2) s.BR69-BR74, il., tab., bibliogr. 31 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • farmacja
  • nefrologia

    Typ dokumentu:
  • badanie porównawcze
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • szczury
  • płeć żeńska

    Streszczenie angielskie: Background: The increased permeability of the glomerular capillary wall in adriamycin nephropathy may be mediated by incrased generation of free radicals, possibility also by the non-enzymatic production of isoprostanes induced by oxidative stress. ACE inhiitors and angiotensin II antagonists may reduce proteinuria, perhaps by decreasing intraglomerular pressure and increasing the selective permeability of the glomerular capillary wall. Material/Methods: We compared the effect of an ACE inhibitor, enalapril, and an angiotensin II atagonist, losartan, on total malodialdehyde in blood and the urinary excretion of certain eicosanodids and their metabolites (TxB2, 6-keto-PGF1a, bicyclo-PGE2 and 8-isoprostane) in experimental adriamycin-induced nephrotic syndrome in rats. Results: Increased proteinuria in adriamycin-treated rats was not prevented by losartan, but tended to be partly mitigated by enalapril. However, both losartan and enalapril prevented the adriamycin-induced increase of total MDA in serum, but urinary excretion of 8-isoprostane was increased in nephrotic rats treated by losartan compared to controls. The enalapril-induced increase in urinary excretion of bicyclo-PGE2 was possibly mediated by kinins. Proteiuria positively correlated with urinary excretion of 8-isoprostane, and proteinuric rats also had a significantly higher urinary excretion of 8-isoprostane than non-proteinuric rats. Conclusions: Proteinuria in the acute phase of adriamycine nephropathy may be dependent on free radical generation and the formation of 8-isoprostane. The mild anitproteinuric effect of enalapril, but not losartan, may suggest the contributory role of the inhibiton of kinin degradation in the antiproteinuric action of enalapril in this model of nephrotic syndrome.

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    Tytuł oryginału: The continuing need for disinterested research.
    Autorzy: Ziman John
    Źródło: Sci. Eng. Ethics 2002: 8 (3) : Conflict of interest and its significance in science and medicine s.397-399 - Międzynarodowa konferencja pt. Konflikt interesów i jego znaczenie w nauce i medycynie Warszawa 05-06.04. 2002
    Sygnatura GBL: 735,647

    Typ dokumentu:
  • praca związana ze zjazdem
  • tytuł obcojęzyczny
  • praca przeglądowa

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