Wynik wyszukiwania w bazie Polska Bibliografia Lekarska GBL

Zapytanie: ZEGADŁO-MYLIK
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Tytuł oryginału: Determination of anti-calreticulin antibodies in sera of children with untreated celiac disease: comparison with anti-endomysial and anti-reticulin antibodies.
Autorzy: Zegadło-Mylik Maria, Cukrowska Bożena, Rujner Jolanta, Syczewska Małgorzata, Socha Jerzy, Woźniewicz Bogdan M.
Źródło: Ann. Diagn. Paediatr. Pathol. 2002: 6 (3/4) s.113-116, tab., bibliogr. 17 poz.
Sygnatura GBL: 313,395

Hasła klasyfikacyjne GBL:
  • pediatria
  • immunologia
  • gastroenterologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dzieci 13-18 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: Calreticulin (CRT) has been identified as one of the autoantigens of anti-gliadin antibodies found in celiac disease. In this study we have examined the validity of serum anti-CRT antibody levels in patients with celiac disease and in control group and assessed their sensitivity and specificity against standard serological tests. Serum IgA anti-CRT antibody levels measured by ELISA and IgA anti-endomysial antibodies (EmA) and IgA anti-reticulin antibodies (ARA) by indirect immunofluorescence were determined in 35 untreated celiac disease and in 24 non-celiac controls. IgA EmA and IgA ARA antibodies were positive in 32 and 34 patients (sensitivity 91,4 and 97,1 p.c.). IgA anti-CRT antibodies were positive in 15 celiac patients out of 33 examined (sensitivity 45,5 p.c.). No controls were ARA, EmA and anti-CRT positive. Our results revealed that anti-CRT antibodies despite their high specificity in IgA (100 p.c.) have limited value in screening programs for celiac disease.

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