Wynik wyszukiwania w bazie Polska Bibliografia Lekarska GBL

Zapytanie: ZAZULA
Liczba odnalezionych rekordów: 4



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Tytuł oryginału: The relationship between gastric cancer cells circulating in the blood and microsatellite instability positive gastric carcinomas.
Autorzy: Czopek J., Bialas M., Rudzki Z., Zazula M., Pituch-Noworolska A., Zembala M., Popiela T., Kulig J., Kołodziejczyk P., Stachura J.
Źródło: Aliment. Pharmacol. Ther. 2002: 16 suppl. 2 s.128-136, il., tab., bibliogr. 31 poz. - 9 Międzynarodowe Sympozjum nt. gastroenterologii Shimoda 26-27.04. 2001
Sygnatura GBL: 306,346

Hasła klasyfikacyjne GBL:
  • gastroenterologia
  • onkologia

    Typ dokumentu:
  • praca kliniczna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: Bacground: Cancers characterized by microsatellite instability may be biologically different from their counterparts with stable microsatellite sequences. Circulating cancers cell present in blood prior to surgery may constitute an adverse prognostic finding. Aim: To correlate these two phenomena with morphological features and survival in advanced gastric cancer. Methods: We examined 76 cases of resected sporadic, advanced gastric cancer by means of routine morphology and a panel of microsatellite markers. Sixty-six cases were screened for presence of cancer cells circulating in blood prior to the surgery using combined morphological and immunocytochemical approach. Results: Twenry-one (27.6 p.c.) cases demonstrated microsatellite instability in at least one locus. Among them 11 (14.5 p.c. showed microsatellite instability in more than 30 p.c. (4/12) examined loci, and they were therefore designated as replication error positive (RER+). Circulating cancer cells were detected in 2/19 microsatellite instability and in 11/47 remaining cases (difference not significant). The survival of the microsatellite instability cases was significantly better. The presence of circulating cancer cells did not correlate with survival. Conclusion: It is possible that the microsatellite instability status, but not circulating cancer cells, constitutes a prognostic predictive factor in advanced gastric carcinoma. Confirmation of this hypothesis requires continuation of patient follow-up.


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    Tytuł oryginału: Synchronous serrated adenoma of the appendix and high-grade ovarian carcinoma: a case demonstrating different origin of the two neoplasms.
    Autorzy: Rudzki Zbigniew, Zazula Monika, Białas Magdalena, Klimek Marek, Stachura Jerzy
    Źródło: Pol. J. Pathol. 2002: 53 (1) s.29-34, il., bibliogr. 12 poz.
    Sygnatura GBL: 301,852

    Hasła klasyfikacyjne GBL:
  • gastroenterologia
  • ginekologia i położnictwo
  • onkologia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca kazuistyczna

    Wskaźnik treści:
  • ludzie
  • dorośli = 65 r.ż.
  • płeć żeńska

    Streszczenie angielskie: Association of mucinous adenomas of the appendix and mucinous ovarian tumors is well known. The origin of the ovarian tumor (metastases from the appendix vs independent primary) is still debated. Serrated adenoma is a rare neoplasm of the distal gastrointestinal tract, and its precancerous role in the colorectum was recently postulated. A 74-year-old patient was subjected to hysterectomy with routine appendectomy due to a 17-cm tumor of her right ovary. Histological examination revealed a high-grade ovarian adenocarcinoma with peritoneal involvement. The appendix, grossly unremarkable, harbored a serrated adenoma with no evidence of invasion or malignant transformation. Immunohistochemical examination revealed CD7+, CK20-phenotype of the ovarian and reverse (CK7-, CK20+) phenotype of the appendiceal tumor. Microsatelite analysis demonstrated microsatellite instability (MSI-high) within the serrated adenoma (4/5 markers with positive amplification) and no MSI (0/6 amplified markers) in the samples from the ovarian carcinoma, its metastases and the univolved uterine cervix. There were also differences in LOH pattern between the ovarian adenocarcinoma and the serrated adenoma. The findings suggest two independent primaries with profound differences in tumorigenetic pathways of both lesions. To the best of our knowledge this the first report of synchronous serrated adenoma of the appendix and ovarian carcinoma.


    3/4

    Tytuł oryginału: Fatal post-transplant lymphoproliferative disorder following allogeneic bone marrow transplantation for aplastic anemia.
    Autorzy: Rudzki Zbigniew, Werda Larissa, Piątkowska-Jakubas Beata, Mensah Patrycja, Zazula Monika, Białas Magdalena, Skotnicki Aleksander B., Stachura Jerzy
    Źródło: Pol. J. Pathol. 2002: 53 (1) s.35-40, il., bibliogr. 13 poz.
    Sygnatura GBL: 301,852

    Hasła klasyfikacyjne GBL:
  • hematologia
  • transplantologia

    Typ dokumentu:
  • praca kazuistyczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • płeć męska

    Streszczenie angielskie: Post-transplant lymphoproliferative disorder (PTLD) constitutes serious complication of allogeneic bone marrow transplantation. We describe a case of PTLD in a twenty-six-old male treated with bone marrow transplantation for aplastic anemia of unknown case. The patient received unmanipulated marrow graft from his HLA-matched brother. Fifty-one days post transplant he developed progressive enlargement of cervical lymph nodes, followed by hepatosplenomegaly and generalized lymphadenopathy. Polymorphic PTLD was diagnosed basing on the lymph node histopathology, positive EBV detection, flow cytometry and IgH rearrangenement studies proving monoclonality (capillary electrophoresis with ABI PRISM 310 genetic Analyzer). There was no response to anti- CD20 antibody, cessation of immunosuppression, donor lymphocyte infusion and cystatic therapy. The patient died on the 65th day of multiple organ failure. We discuss the diagnostics and management of PTLD in the setting of bone marrow transplantation.


    4/4

    Tytuł oryginału: Microsatellite instability and gastrointestinal carcinoma: a never-ending story.
    Autorzy: Stachura Jerzy, Popiela Tadeusz, Czopek Jacek, Zazula Monika, Rudzki Zbigniew, Okoń Krzysztof, Kulig Jan, Białas Magdalena, Kołodziejczyk Piotr, Sińczak Anna, Papla Bolesław
    Źródło: Prz. Epidemiol. 2002: 56 supl.: Conference on molecular epidemiology in preventive medicine - achievements and new challenges s.83-93, il., bibliogr. 39 poz. - Konferencja pt. Molekularna epidemiologia w medycynie prewencyjnej - osiągnięcia i nowe wyzwania Kraków 20-22.06. 2002
    Sygnatura GBL: 301,250

    Hasła klasyfikacyjne GBL:
  • genetyka
  • gastroenterologia
  • onkologia

    Typ dokumentu:
  • praca związana ze zjazdem
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: We briefly review the current status of the research on the microsatellite status of colorectal and gastric carcinomas basing on the literature and our own studies. Investigation of microsatellite instability (MSI) is possible in archival material, and may by applied to analysis of relatively large retrospective series of cases. A specific profile of MSI-H (high) colorectal carcinomas, including right-sided location, mucinous an dsolid histology, and predominance of high-grade cases is a constant finding regardless of the geographical origin of the studied population, despide the fact that other aspects of colorectal cancer pathology differ markedly among various ethnic groups. The MSI-H tumors present several several intuively associated with bad prognosis, including the highest Ki67 proliferative fraction, but paradoxically may be associated with a more favorable outcome than MSS (stable) or MSI-L (low) cancers. The distinct status of the MSI-L colorectal cancers ("mild mutator pathway") is still unclear, but some reports, including our study, suggest that this group may present specific biologic features not necessarily placing it among MSS and MSI-H tumors. In gastric carcinoma the better prognosis linked to the MSI status emerges more and more firmly from the plethora of conflicting data. MSI-L gastric carcinomas may contain disproportionally high percentage of EBV-positive cases. The comparative aspect of the microsatellite research suffers from lack of widely acccepted standardized procedures aimed at detection of MSI, and from inconsistency in defining the MSS, MSI-L and MSI-H phenotypes among various authors.

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