Wynik wyszukiwania w bazie Polska Bibliografia Lekarska GBL

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Tytuł oryginału: Ultrasound and biochemical evaluation of liver regeneration process after resections for primary and metastatic tumors.
Autorzy: Kulig Jan, Nowak Wojciech, Popiela Tadeusz, Sobocki Jacek, Zarębski Bartosz
Źródło: Hepatogastroenterology 2002: 49 (44) s.349-353, il., tab., bibliogr. 20 poz.
Sygnatura GBL: 304,355

Hasła klasyfikacyjne GBL:
  • chirurgia
  • gastroenterologia
  • onkologia

    Typ dokumentu:
  • praca kliniczna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: background/Aims: The liver regeneration process after resective procedures is an important clinical problem especially in view of the growing population of patients requiring liver transplantations or undergoing resective procedures as well as those with toxic or viral liver injures. The aim of the study was to analyze liver regeneration potential using ultrasound examination, and liver function biochemical tests in the patients after liver resections. Methodology: Twenty-one patients with primary or metastatic liver cancer were included in the study (17 males, 4 females, mean age: 59.8, SD 10:3). The patients were undergoing gastrointestinal tract primary tumor resections with extended lymphandenectomy and liver metastatic tumor excisions. Liver volume was measured postoperatively in the follow-up ultrasound examinations and biochemical tests were performed before and after the procedure. Liver function and activity of p-450 cytochrome was tested with IRIS 13C stable isotope breath analyzer. Results: The mean time of follow-up was 12.6 months (SD 7.8) during which volume of liver increased on average in the first five months to 105.7, 112.1, 125.7, 131.2, and 138.4 p.c. of the immediate postoperative value. Biochemical parameters returned to normal after 2-3 weeks. Four patients in whom liver failed to regenerate died due to cancer spread in the mean time of 6.5 months. Conclusions: Liver has tremendous regeneration potential. In spite of this fact, extended hepatectomies affect largely the functionaln status of residual parenchyma which may lead to a fatal outcome.

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    Tytuł oryginału: IL-1-mediated inhibition of IL-6-induced STAT3 activation is modulated by IL-4, MAP kinase inhibitors and redox state of HepG2 cells.
    Autorzy: Cisowski Jarosław, Zarębski Adrian, Koj Aleksander
    Źródło: Folia Histochem. Cytobiol. 2002: 40 (4) s.341-345, il., tab., bibliogr. 21 poz.
    Sygnatura GBL: 304,846

    Hasła klasyfikacyjne GBL:
  • immunologia
  • gastroenterologia
  • onkologia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • in vitro

    Streszczenie angielskie: It is known that during acute phase reaction IL-6 activates STAT3 in hepatoma cells and IL-1 downregulates this response. We found that the inhibitory properties of IL-1 on STAT signaling cascade in human hepatoma HepG2 cells are considerably decreased not only in the presence of MAP kinase inhibitors SB203580 and PD98059 but also by some antixidants (N-acetyl cysteine and pyrrolidine dithiocarbamate) and by anti-inflammatory cytokine IL-4. It appears that cytokien crosstalk between IL-6 and IL-1 includes a direct pathway sensitive to antioxidants and MAP kinase inhibitors, whereas the indirect prolonged response depends probably on synthsis of suppressors of cytokine signalling (SOCS).

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