Wynik wyszukiwania w bazie Polska Bibliografia Lekarska GBL

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Tytuł oryginału: Imipramine but not 5-HT1A receptor agonists or neuroleptics induces adaptive changes in hippocampal 5-HT1A and 5-HT4 receptors.
Autorzy: Zahorodna Agnieszka, Tokarski Krzysztof, Bijak Maria
Źródło: Eur. J. Pharmacol. 2002: 443 (1/3) s.51-57, il., bibliogr. s. 56-57
Sygnatura GBL: 312,088

Hasła klasyfikacyjne GBL:
  • farmacja

    Typ dokumentu:
  • badanie porównawcze
  • praca doświadczalna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • szczury

    Streszczenie angielskie: It has been reported that the treatment with a tricyclic antidepressant imipramine induces an increase in the sensitivity of 5-HT1A receptors and a decrease in the sensitivity of 5-HT4 receptors in the rat hippocampus. 5-HT1A receptor agonists and neuroleptics also affect 5-HT1A receptors in different brain areas; therefore, it was of interest to compare their effects on hippocampal 5-HT receptors with the influence of the well-established antidepressant imipramine. We studied the effects of repeated treatment with imipramine, the 5-HT1A receptor agonists 8-hydroxy-2(di-n-propylamino)tetralin (8-OH-DPAT) and buspirone, and the neuroleptics haloperidol and clozapine on the sensitivity of rat hippocampal CA1 neurons to 5-HT1A - and 5-HT4 receptor activation. Imipramine was administered for 21 days (10 mg/kg p.o., twice daily), 8-OH-DPAT for 7 days (1 mg/kg s.c., twice daily) and buspirone for 21 days (5 mg/kg s.c., twice daily). The rats received haloperidol (1 mg/kg) and clozapine (30 mg/kg) for 6 weeks in drinking water. Hippocampal slices were prepared 2 days after the last treatment with imipramien, 8-OH-DPAT or buspirone, and 5 days after the last treatment with the neuroleptics. Using an extracelllar in vitro recording, we studied changes in the amplitude of stimulation-evoked population spikes, induced by 5-HT, 8-OH-DPAT and the 5-HT4 receptor agonist zacopride. Activation of 5-HT1A receptors decreased, while activation of 5-HT4 receptors increased the amplitude of population spikes. Imipramine significatly enhanced the inhibitory effects of 5-HT and 8-OH-DPAT, and attenuated...

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    Tytuł oryginału: Zastosowanie modelu spontanicznej aktywności napadowej w badaniach zmian adaptacyjnych reaktywności receptorów serotoninowych.
    Tytuł angielski: Electrophysiological studies on adaptive changes of serotonin receptors using spontaneous epileptiform activity in neuronal network.
    Autorzy: Bobula Bartosz, Zahorodna Agnieszka, Tokarski Krzysztof, Hess Grzegorz
    Źródło: Post. Hig. 2002: 56 (3) s.377-383, il., bibliogr. [12] poz., sum. - Konferencja pt. Blaski i cienie elektrofizjologii mózgu in vitroKonferencja pt. Techniki elektrofizjologiczne w badaniach zjawisk bioelektrycznych - od kanałów jonowych po sieci neuronalne KrakówŁódź 24.10.07-08.06. 20012002
    Sygnatura GBL: 301,727

    Hasła klasyfikacyjne GBL:
  • farmacja
  • neurologia

    Typ dokumentu:
  • praca związana ze zjazdem

    Wskaźnik treści:
  • ludzie
  • zwierzęta

    Streszczenie angielskie: Certain antidepressant medications exert effects of the serotonergic (5-HT) system but their mechanisms are still not well understood. Using extracellular ex vivo recording of spontaneous, epileptiform activity of neurons we determined changes in the reactivity of cortical and hippocampal slices to agonists of main subtypes 5-HT receptors, induced by repeated administration of the antidepressants. Repeated tratment with antidepressants enhances the 5-HT-mediated inhibition in both frontal cortex and hippocampal regions. Drugs administration induce opposite adaptive changes within 5-HT2 and 5-HT1A receptors in frontal cortex as well as in 5-HT1A receptors in frontal cortex as well as in 5-HT1A and 5-HT4 receptors in the hippocampus. These effects may contribute to therapeutic effects of antidepressants administration.

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    Tytuł oryginału: Differential effects of repeated imipramine on hippocampal responsiveness to adenosine and serotonin.
    Autorzy: Zahorodna Agnieszka, Bijak Maria, Hess Grzegorz
    Źródło: Eur. Neuropsychopharmacol. 2002: 12 (4) s.355-360, il., bibliogr. [23] poz.
    Sygnatura GBL: 313,361

    Hasła klasyfikacyjne GBL:
  • farmacja
  • neurologia

    Typ dokumentu:
  • praca doświadczalna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • szczury

    Streszczenie angielskie: Imipramine-induced enhacement of the inhibitory action of 5-HT1A receptor activation in hippocampal pyramidal neurons has been attributed to alterations in the transduction mechanism that involves G protein-dependent opening of K+ channels. Postsynaptic 5-HT1A and adenosine A1 receptors may share that transduction pathway. We investigated the influence of repeated imipramine administration on 5-ht1A and adenosine A1 receptor-mediated effects in rat hippocampal slices. Repeated imipramine selectively enhanced the postsynaptic effects of 5-HT1A receptor activation hyperpolarization and reduction of input resistance of neurons and reduction of the population spike amplitude. In contrast, after imipramine treatment only the presynaptic effect of adenosine receptor agonist, a decrease of the field excitatory postsynaptic potential, was enhanced. The data demonstrate that alterations in the presumed common transduction mechanism that was postulated for the 5-HT1A and adenosine A1 receptor-mediated activation of K+ channels are not involved in the effect of repeated imipramine administration.

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