Wynik wyszukiwania w bazie Polska Bibliografia Lekarska GBL

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Tytuł oryginału: Assessment of long-term effects of exposure to toluene based on the analysis of selected behavioral responses with particular reference to the ability to trigger behavioral hypersensitivity in rats.
Autorzy: Wiaderna Dorota, Tomas Tadeusz
Źródło: Int. J. Occup. Med. Environ. Health 2002: 15 (3) s.239-245, il., bibliogr. 20 poz.
Sygnatura GBL: 306,313

Hasła klasyfikacyjne GBL:
  • toksykologia
  • neurologia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • szczury
  • płeć męska

    Streszczenie angielskie: Toluene is a major component of numerous commercial organic solvent formulations. It is often listed among the chemicals capable of producing the organic solvent syndrome and a neurobehavioral hypersensitivity condition. The hypersensitivity condition (continued long-term intensification of some behavioral reactions in response to pharmacological or environmental stressor) is usually associated with the increased tonus of the functional dopaminergic system. The aim of our current research was to determine whether, under conditions of inhalation exposure, toluene can produce long-term behavioral changes or modify the intensity of the behavioral response to apomorphine, a dopaminergic receptor agonist. In our experiment, male rats were exposed to 25, 100 and 250 ppm toluene for 4 weeks (5 days/week, 6h/day). The following behaviors were tested: finding water in a radial maze; open field motor activity; acquiring the conditional response of passive avoidance; sensitivity to a thermal pain stimulus (hot plate test) and changes in this sensitivity caused by stress; and acquiring the conditional response of two-directional active avoidance. The behavioral response to apomorphine, i.e. the increased spontaneous locomotor activity, was assessed on day 10 after the termination of the exposure in the rotary drum test. In the behavioral experiment, significant differences between groups were recorded only for hot plate test; in the 100 and 250 ppm rats, electric-shock-related anxiety response was stronger than in the control group. In the experiment using pharmacological provocation...


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    Tytuł oryginału: Behavioral sensitivity to amphetamine after repeated exposure to an organophosphorous pesticide in the rat. Effect of coexposure to restraint.
    Autorzy: Gralewicz Sławomir, Wiaderna Dorota, Lutz Piotr
    Źródło: Int. J. Occup. Med. Environ. Health 2002: 15 (3) s.229-238, il., tab., bibliogr. 30 poz.
    Sygnatura GBL: 306,313

    Hasła klasyfikacyjne GBL:
  • toksykologia
  • neurologia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • szczury
  • płeć męska

    Streszczenie angielskie: In the work environment, chemical stressors coexists frequently with physical or psychological stressors. The purpose of the present experiment was to find out whether the effects of a repeated exposure to chlorphenvinphos (CVP), an organophosphorus pesticide, could be modified by a concurrent exposure to restraint, a psychological stressor. The experiment was performed on male Wistar rats. CVP was administered ten times (one injection/day) at doses of 0.5 or 1.0 mg/kg i.p. (1/20 and 1/10 of LD50, respectively) within a period of two weeks. A half of the rats from each group were immobilized in restraint chambers for 120 min/day starting 10-15 min after CVP injection. In each rat, the effect of 0.5 mg/kg of amphetamine (AMPH) and 0.75 mg/kg of scopolamine (SCOP) on motor activity in an open-field was tested three weeks or six weeks (in rats exposed to 0.5 mg/kg or 1.0 mg/kg doses of CVP, respectively) after the last exposure day. No clear cut effect on the behavioral responsiveness to AMPH or SCOP were noted in rats subjected to repeated restraint, repeated 0.5 mg/kg doses of CVP, or combination of these two stressors. In rats exposed to CVP at the 1.0 mg/kg doses, the behawioral response to AMPH was augmented and this effect was not apparently altered in rats coexposed to restraint. The above result indicates that the repeated exposure to CVP may lead to functional alterations within the central nervous system and that coexposure to restraint neither facilitates nor prevents these alterations from development.


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    Tytuł oryginału: Assessment of long-term neurotoxic effects of exposure to mesitylene (1,3,5-trimethylbenzene) based on the analysis of selected behavioral responses.
    Autorzy: Wiaderna Dorota, Gralewicz Sławomir, Tomas Tadeusz
    Źródło: Int. J. Occup. Med. Environ. Health 2002: 15 (4) s.385-392, il., bibliogr. 21 poz.
    Sygnatura GBL: 306,313

    Hasła klasyfikacyjne GBL:
  • toksykologia
  • neurologia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca doświadczalna

    Wskaźnik treści:
  • zwierzęta
  • szczury
  • płeć męska

    Streszczenie angielskie: Trimetylbenzene isomers: pseudocumene, hemimellitene and mesitylene, are major components of numerous commercial solvents and high-grade fuels. In our earlier research on rats we have proved that inhalation exposure to pseudocumene of hemimellitene at concentrations close to the MAC value resutls in behavioral changes detectable many weeks after cessation of the exposure. The aim of our present study is to determine whether exposure to mesitylene causes effects similar to those observed for pseudocumene and hemimellitene. Male rats were used in the experiment. The animals were exposed in the inhalation chambers to mesitylene vapors at the following concentrations: 0 ppm - group MESO; 25 ppm (125 mg/m3) - group MES25; 100 ppm (500 mg/m3) - group MES100 and 250 ppm (1250 mg/m3) - gropu MES250 for 4 weeks (6 h/day, 5 days/week). The following behaviors were tested: 1) ability to find water in a radial maze (14-19 days after the exposure); 2) open field locomotor activity (25 days after the exposure); 3) acquiring the conditioned reaction of active avoidance (35-45 days after the exposure); 4) sensitivity to pain and stress-induced changes of pain sensitivity (50-51 days after the exposure); and 5) acquiring the conditioned reaction of two-way active avoidance (54-60 days after the exposure). Significant between-group differences were noted in passive and active avoidance tests and sensitivity to pain. In the Mes25, MES100 and MES250 rats, the persistence of the passive avoidance reaction was shorter, and more trials were required to produce the active avoidance reaction than in controls (group MESO), the MES100 group appeared to be more fearful on the second day of testing on the hot plate...

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