Wynik wyszukiwania w bazie Polska Bibliografia Lekarska GBL

Zapytanie: WESOŁOWSKA
Liczba odnalezionych rekordów: 8



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Tytuł oryginału: In the search for selective ligands of 5-HT5, 5-HT6 and 5-HT7 serotonin receptors.
Autorzy: Wesołowska Anna
Źródło: Pol. J. Pharmacol. 2002: 54 (4) s.327-341, il., tab., bibliogr. 65 poz.
Sygnatura GBL: 313,156

Hasła klasyfikacyjne GBL:
  • farmacja

    Typ dokumentu:
  • tytuł obcojęzyczny

    Streszczenie angielskie: In recent years much attention has been focused on the functional importance of 5-HT5, and 5-HT6 and 5-HT7 receptors in the pathogenesis of neuropsychiatric and other diseases. In this connection, intensive studies with ligands of these receptors are currently in progress. Recognition of the structural characteristics responsible for the bilding of a ligand molecule to an appropriate receptor, and development of an active complex have reached an advanced stage in the research for selective compounds. This review was undertaken to summarize the results of structure-activity relationship studies with ligands of 5-HT5, 5HT6 and 5-HT7 receptors. Additionally, some data on localization, pharmacological properties and the functional role of those receptors were reported.

    2/8

    Tytuł oryginału: Pharmacological analysis of the hypothermic effects of NAN-190 and its analogs, postsynaptic 5-HT1A receptor antagonists, in mice.
    Autorzy: Wesołowska Anna, Borycz Jolanta, Paluchowska Maria H., Chojnacka-Wójcik Ewa
    Źródło: Pol. J. Pharmacol. 2002: 54 (4) s.391-399, il., tab., bibliogr. 40 poz.
    Sygnatura GBL: 313,156

    Hasła klasyfikacyjne GBL:
  • farmacja

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • myszy
  • płeć męska

    Streszczenie angielskie: In this study, we examined the role of 5-hydroxytryptamine (5-HT)1A and ŕ1-adrenergic receptors in the hypothermia induced by 1-(2-methoxyphenyl)-4-[4-(2-phthalimido)butyl]-piperazine (NAN-190) and its analogs, 1-(2-methoxyphenyl)-4-[(4-succinimido)butyl]piperazine (MM77) and trans-1(2-methoxyphenyl)-4-[4-(2-phthalimido)cyclohexyl]piperazine (MP245), which - like NAN-190 - showed a high affinity for 5-HT1A and ŕ1-adrenoceptors. Administration of NAN-190 (a partial agonist of presynaptic and an antagonist of postsynaptic 5-HT1A receptors and ŕ1-adrenoceptors), MM77 and MP245 (antagonists of postsynaptic 5-HT1A receptors), as well as 8-OH-DPAT (a 5-HT1A agonist) and prazosin (an ŕ1-adrenoceptor antagonist) induced a dose-dependent hypothermia in mice. The silent antagonist of 5-HT1A receptors, WAY 100635, which abolished the hypothermic effect of 8-OH-DPAT, inhibited the hypothermia induced by NAN-190 administered at a dose of 1 mg/kg (but not 2 mg/kg) and by MP245 (0.5 and 1 mg/kg), but failed to change the MM77 (1 and 4 mg/kg)-induced decrease in body temperature in mice. The ŕ1-adrenoceptor agonist St587, which reduced the hypothermic effect of prazosin, inhibited the decrease in body temperature evoked by NAN-190 at the higher dose and by MP245at both the doses used, but did not affect the MM77-induced hypothermia in mice. The obtained results suggest that the hypothermia in mice induced by NAN-190 and its constrained analog MP245 is connected with stimulation of 5-HT1A receptors and with blockade of ŕ1-adrenoceptors, participation of these receptors not being equivalent, though. The origin of the hypothermia evoked by MM77 is still unknown.

    3/8

    Tytuł oryginału: Czy można odróżnić radial scar od raka inwazyjnego sutka - konfrontacja obrazu mammograficznego z badaniem histopatologicznym.
    Tytuł angielski: Can radial scar be differentiated from breast cancer? Mammographic and pathological correlations.
    Autorzy: Wesołowska Ewa, Tuziak Tomasz, Pietrow Danuta, Oknińska Justyna, Dziewulska Ewa, Nagadowska Monika
    Źródło: Pol. J. Radiol. 2002: 67 (4) s.66-71, il., tab., bibliogr. 16 poz., sum.
    Sygnatura GBL: 301,279

    Hasła klasyfikacyjne GBL:
  • chirurgia
  • ginekologia i położnictwo
  • onkologia
  • radiologia

    Typ dokumentu:
  • praca kliniczna

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.
  • płeć żeńska

    Streszczenie angielskie: Background: The radial scar is benign breast lesion; its radiological and microscopic appearance may simulate invasive carcinoma. The purpose of the study was to analyse and correlate mammographic and histologic findings in patients with radial scar. Radial scar was compared with breast cancer of stellate appearance in mammography. Material/Methods: Between May 1994 and December 2000 129 women were examined due to the stellate lesion of the breast. All mammograms were evaluated for appearance of the spicule, density and size of the central core, presence of microcalcifications. Clinical records were analyzed to determine age, any evidence of palpable lesion and to establish the role of fine needle aspiration biopsy (FNAB) and ultrasound in radial lesions. Results: Pathology revealed 68 cases fo radial scar, 43 invasive carcinomas and 18 cases of radial scar with associated borderline lesions (atypical ductal hyperplasia, lobular carcinoma in situ) or malignant lesions (ductal carcinoma in situ, tubular cancer). Mammography examination presented no differences between benign and malignant lesions. Neither the ultrasound appearances nor cytology could be used to differentiate between radial scar and breast carcinoma. Conclusions: In conclusion, radial lesions need to be surgically excised to determine microscopic diagnosis.

    4/8

    Tytuł oryginału: Screening the human expression library for protein interaction with vacuolating cytotoxin (VacA) of Helicobacter pylori.
    Autorzy: Wesołowska Aleksandra, Ostrowski Jerzy
    Źródło: Prz. Epidemiol. 2002: 56 supl.: Conference on molecular epidemiology in preventive medicine - achievements and new challenges s.331-337, il., bibliogr. 15 poz. - Konferencja pt. Molekularna epidemiologia w medycynie prewencyjnej - osiągnięcia i nowe wyzwania Kraków 20-22.06. 2002
    Sygnatura GBL: 301,250

    Hasła klasyfikacyjne GBL:
  • genetyka
  • mikrobiologia
  • gastroenterologia

    Typ dokumentu:
  • praca związana ze zjazdem
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • in vitro

    Streszczenie angielskie: Vacuolating cytotoxin (VacA) is the main virulence factor of Helicobacter pylori, a well-recignized pathogen that infects up to 50 p.c. of the world's human population. Infection with Helicobacter pylori is associated with both antral gastritis and duodenal ulcer and increases the risk of gastric adenocarcinoma. According to epidemiological data, the stage of the disease depends on the genetic diversity of vacA between the different strain of bacteria. In fact pathogenesis may depend on both bacterial and the human genotype. Specific protein interactions could constitute the molecular mechanism responsible for this correlation and therefore the human proteins binding to VacA were indentified. Using VacA as bait in a yeast two hybrid system the cDNA library representing the sequence expressed as mRNA in the tissue of gastric patient infected with Helicobacter pylori was screened. Results indicate that there is an interaction between the carboxy-terminal fragment of VacA with the subunit á of human trimeric protein G. With reference to the earlier stidies with several bacterial toxins that modify G proteins it is not unlikely that this interaction influences the Helicobacter pylori pathogenesis.

    5/8

    Tytuł oryginału: 50-lecie pracy naukowej prof. dr hab. Lutosławy Marii Skrzypczak.
    Tytuł angielski: 50 years of scientific work of prof. dr. hab. Lutosława Maria Skrzypczak.
    Autorzy: Thiem Barbara, Wesołowska Maria, Budzianowski Jaromir
    Źródło: Farm. Pol. 2002: 58 (22) s.1073-1075, il.
    Sygnatura GBL: 310,851

    Hasła klasyfikacyjne GBL:
  • farmacja

    Typ dokumentu:
  • praca biograficzna

    Wskaźnik treści:
  • ludzie
  • płeć żeńska
  • historia nowożytna
  • historia XX wieku
  • historia XXI wieku

    Temat osobowy:
  • Skrzypczak
  • Lutosława Maria 1925-

    6/8

    Tytuł oryginału: Wizerunek organizacji a sytuacja kryzysowa.
    Autorzy: Wesołowska Ewa
    Źródło: Antidotum 2002: 11 (11) s.27-35, bibliogr. 13 poz.
    Sygnatura GBL: 306,358

    Hasła klasyfikacyjne GBL:
  • organizacja ochrony zdrowia

    7/8

    Tytuł oryginału: Novel N-{omega-[4-(2-methoxyphenyl)piperazin-1-yl]-ethyl}pyrid-2(1H)-ones with diversified 5-HT 1A receptor activity.
    Autorzy: Paluchowska Maria H., Bugno Ryszard, Charakchieva-Minol Sijka, Wesołowska Anna, Chojnacka-Wójcik Ewa
    Źródło: Pol. J. Pharmacol. 2002: 54 (6) s.641-646, il., tab., bibliogr. 22 poz.
    Sygnatura GBL: 313,156

    Hasła klasyfikacyjne GBL:
  • farmacja

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • szczury
  • płeć męska
  • in vitro

    Streszczenie angielskie: Novel omega-[4-(2-methoxyphenyl)piperazin-1-yl]ethyl derivatives 1-6 containing 4-, 5- and/or 6-arylsubstituted pyrid-2(1H)-one moiety were synthesized. All the new compounds were examined in vitro to assess their 5-HT 1A and 5-HT 2A receptor affinities. Compounds 3 and 4 with a 5- or a 6-phenylsubstituted pyridone ring demonstrated high 5-HT 1A receptor affinity (Ki=17 and 38 nM, respectively) and were tested in behavioral functional models. Derivative 3 can be regarded as a weak 5-HT 1A postsynaptic antagoninist, whereas 4 showed features of a weak partial agonist of 5-HT 1A receptors (an agonist of pre- and an antagonist of posstynaptic ones). Binding affinities and in vivo results were discussed in comparison with those for the previously described tetramethylene analogs. The obtained results showed that the shortening of the aliphatic chain to two methylene groups exposed the intrinsic activity of the ligand 4 and 5-HT 1A receptor sites.

    8/8

    Tytuł oryginału: Napięciowe bóle głowy u dzieci - analiza kliniczno-epidemiologiczna ze szczególnym uwzględnieniem etiologii, oraz możliwości terapeutycznych : praca doktorska
    Autorzy: Wesołowska Marzenna, Czerwionka-Szaflarska Mieczysława (promot.).; Akademia Medyczna Wojewódzka Poradnia Neurologiczna Dziecięca w Bydgoszczy, Wojewódzki Szpital Dziecięcy Oddział Neurologii
    Źródło: 2002, 161, [3] k. : il., tab., bibliogr. 264 poz., streszcz., maszyn.
    Sygnatura GBL: 45/20722

    Hasła klasyfikacyjne GBL:
  • pediatria
  • neurologia

    Typ dokumentu:
  • praca epidemiologiczna
  • praca doktorska

    Wskaźnik treści:
  • ludzie
  • dzieci 2-5 r.ż.
  • dzieci 6-12 r.ż.
  • dzieci 13-18 r.ż.
  • płeć męska
  • płeć żeńska

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