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Tytuł oryginału: Chronic alpha1-adrenergic blockade improves hypertension and renal injury in L-NAME and low-renin L-NAME-DOCA hypertensive rats.
Autorzy: Wangesteen Rosemary, O'Valle Francisco, Moral Raimundo G. Del, Vargas F‚lix, Osuna Antonio
Źródło: Med. Sci. Monitor 2002: 8 (9) s.BR378-BR384, il., tab., bibliogr. 25 poz.
Sygnatura GBL: 313,278

Hasła klasyfikacyjne GBL:
  • farmacja
  • kardiologia
  • nefrologia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca doświadczalna

    Wskaźnik treści:
  • zwierzęta
  • szczury
  • płeć męska

    Streszczenie angielskie: Background: The present study investigated the contribution of ŕ1-adrenergic blockade to hypertension induced by long-term blockade of nitric oxide and chronic treatment with deoxycorticosterone acetate (DOCA), which produced a low renin model of hypertension. We studied the effects of chronic administration of prazosin, an ŕ1-receptor antagonist, on blood pressure (BP), renal injury, and other variables in Nomega-nitro-L-arginine methyl ester (L-NAME) and L-NAME+DOCA hypertensive rats. Material/methods: The rats were divided into 6 groups: Control, DOCA, L-NAME, L-NAME+DOCA, L-NAME+prazosin, and L-NAME+DOCA+prazosin. Tail systolic BP was measured twice a week. After a 6-week evolution, mean arterial pressure (MAP) was measured, along with selected metabolic, morphological and renal variables. Results: The final MAP values were 105 ń 1 for Control, 107 ń 0.6 for DOCA, 153 ń 3 for L-NAME, 175 ń 2 for L-NAME+DOCA, 126 ń 2 for L-NAME+prazosin and 127 ń 5 for L-NAME+DOCA+prazosin. Proteinuria and hyaline arteriopathy were prevented in L-NAME+prazosin rats and markedly attenuated int eh L-NAME+DOCA+prazosin group. Plasma urea and creatinine were significantly increased in teh L-NAME+DOCA group, but not in the L-NAME+DOCA+prazosin group as against controls. The DOCA and DOCA+L-NAME groups showed relative renal and cardiac hypertrophy, which was not observed in teh DOCA+L-NAME+prazosin group. Cocnlusions: ŕ1-adrenergic tone plays and important role in the increased BP and renal injury of L-NAME hypertension. Our results also indicate that when PRA is suppressed by DOCA in L-NAME hypertension, the increased BP and renal injury are largely dependent on the ŕ1-adrenergi tone.

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