Wynik wyszukiwania

myszy

Streszczenie angielskie: The biotransformation of endomorphin-1 (EM-1) by brain synaptic membranes has ben studied. Peptide fragments of EM-1 that were formed during incubation with membrane preparations in vitro were isolated by High-performance liquid chromatography (HPLC) and characterized using determination of amono acid composition. At pH 7.4, two degradation products, EM-1(1-3) and EM-1(1-2), were identified. EM-1 was degraded 77.5 p.c. at 30 min incubation with synaptic membranes. The time course of the experiments and the effect of carboxypeptidase inhibitor (CPI) demonstrated that the proteolysis reaction involves the participation of carboxypeptidase activity.

2/10

Tytuł oryginału: The role of dendritic cells in neurodegenerative diseases.
Autorzy: Iribarren Pablo, Cui You-Hong, Le Yingying, Wang Ji Ming
Źródło: Arch. Immunol. Ther. Exp. 2002: 50 (3) s.187-196, il., bibliogr. 92 poz.
Sygnatura GBL: 304,223

Hasła klasyfikacyjne GBL:

neurologia

Typ dokumentu:

tytuł obcojęzyczny

Wskaźnik treści:

zwierzęta

Streszczenie angielskie: Dendritic cells (DCs) are the most potent antigen-presenting cells (APCs) involved in the induction of adaptive immune responses. The presence of DCs in the central nervous system (CNS) and the active participation of the immune system in a variety of neurodegenerative diseases have been demonstrated. This review will discuss recent findings pertinent to DCs and other antigen-presenting cells in the CNS in health and disease states.

3/10

Tytuł oryginału: Induction of cytokine production in human T cells and monocytes by highly purified lipoteichoic acid: involvement of Toll-like receptors and CD14.
Autorzy: Ellingsen Espen A., Morath Siegfried, Flo Trude H., Schromm Andra B., Hartung Thomas, Thiemermann Christoph, Espevik Terje, Golenbock Douglas T., Foster Simon J., Solberg Rigmor, Aasen Ansgar O., Wang Jacob E.
Źródło: Med. Sci. Monitor 2002: 8 (5) s.BR149-BR156, il., bibliogr. 29 poz.
Sygnatura GBL: 313,278

Hasła klasyfikacyjne GBL:

mikrobiologia

farmacja

hematologia

Typ dokumentu:

praca doświadczalna

tytuł obcojęzyczny

Wskaźnik treści:

in vitro

Streszczenie angielskie: Pro-inflammatory potential of lipoteichoic acid (LTA) from Staphylococcus aureus is controversial. Present study was undertaken to examine ability of highly purified and characterized S. aureus LTA to stimulate production of pro-inflammatory cytokines in human leukocytes at both mRNA and protein level, and to study involvement of Toll-like receptors (TLRs) adn CD14 in this response. Purified LTA was administered to whole human blood ex-vivo (or primary adherent monocytes) and cytokine response assessed in plasma by EIA. Cytokine mRNA was measured by RT-PCR on leukocyate subsets isolated following stimulation. To study involvement of specific receptors for LTA signaling, CHO cells transfected with CD14 and/or TLR2, TLR4 were used, as well as antibodies directed against these receptors. Addition of highly purified LTA to a whole blood or primary adherent monocytes elicited a time and concentration dependent release of TNF-ŕ, IL-1á, IL-6 and IL-8. mRNA encoding TNF-ŕ, IL-1á, IL-6 and IL-8. mRNA encoding TNF-ŕ, IL-1á and IL-6 seemed to be accumulated in monocytes and T cells, but not in granulocytes and B cells. Expression of TLR2, but not TLR4, in chinese hamster ovary cells conferred responsiveness to LTA. However, antibodies directed towards TLR2 (clone TL2.1) or TLR4 (clone THA125) failed to inhibit TNF-ŕ release induced by LTA in the whole blood model and in adherent monocytes. In contrast, blockade of the CD14 receptor with MAb18D11 strongly attenuated LTA induced release of TNF-ŕ in both models.

4/10

Tytuł oryginału: Hepatic cirrhosis increases sensitivity of kidney to endotoxin in rats.
Autorzy: Liu Jian-Jun, Wang Ji-Yao, Zhang Chi, Nilsson Ake, Duan Rui-Dong
Źródło: Med. Sci. Monitor 2002: 8 (2) s.BR56-BR60, il., bibliogr. 31 poz.
Sygnatura GBL: 313,278

Hasła klasyfikacyjne GBL:

gastroenterologia

nefrologia

Typ dokumentu:

praca doświadczalna

tytuł obcojęzyczny

Wskaźnik treści:

szczury

Streszczenie angielskie: Background: Renal failure in cirrhotic patients is a severe complication and endotoxemia might be involved. We investigated the effect of endotoxin on renal function of cirrhotic rats and the potential protective role of N-acetylcysteine (NAC). Material/Methods: Hepatic cirrhosis was generated in a rat model by carbon tetrachloride. Both cirrhotic and normal rats were insulted by endotoxin intravenously, while another cirrhotic group was pretreated with NAC. Blood urea nitrogen (BUN) and creatinine were assayed eight hours later. The changes in serum tumor necrosis factor-ŕ (TNF-ŕ) were assayed by ELISA. The histological changes in the kidney were observed after hematoxylinand eosin staining. Results: Endotoxin increased the BUN and creatinine levels in both normal and cirrhotic rats, with a much higher elevation in the latter group. TNF-ŕ concentration was also increase by endotoxin; the changes are positively correlated with BUN and creatinine. NAC pretreatment sigificantly attenuates the effects of endotoxin on BUN, creatnine and TNF-ŕ levels in cirrhotic rats with no improvement in systemic toxicity symptoms. There were no obvious histological changes in the kidney of these animals. Conclusion: Hepatic cirrhosis increased the sensitivity of renal function to endotoxemia, which may be protected by NAC.

5/10

Tytuł oryginału: Predicting outcome in hematological stem cell transplantation.
Autorzy: Dickinson Anne M., Cavet James, Cullup Hannah, Wang Xiao N., Jarvis Mark, Sviland Lisbet, Middleton Peter G.
Źródło: Arch. Immunol. Ther. Exp. 2002: 50 (6) s.371-378, il., tab., bibliogr. 62 poz.
Sygnatura GBL: 304,223

Hasła klasyfikacyjne GBL:

genetyka

transplantologia

Typ dokumentu:

tytuł obcojęzyczny

Wskaźnik treści:

myszy

Streszczenie angielskie: This review summarizes recent results investigating the role of certain cytokine gene polymorphisms, including those of TNF-ŕ, IFN-ç, IL-6, IL-10 and IL-1 receptor antagonist (IL-1Ra), in allogeneic stem cell trasplantation. It discusses their role in predicting outcome and the development of a genetic risk index for graft versus host disease (GvHD) in HLA-matched sibling transplants. By the comparative use of an in vitro human skin explant model, initial results suggest than certain cytokine gene polymorphisms may be associated with more severe disease.

6/10

Tytuł oryginału: Alergiczny nieżyt nosa i jego wpływ na astmę. Raport ARIA (Allergic Rhinitis and its Impact on Asthma). Raport przygotowany we współpracxy ze Światową Organizacją Zdrowia.
Autorzy: Bousquet Jean, Cauwenberge Paul B. van, Khaltaev Nikolai, Ait-Khaled Nadia, Annesi-Maesano Isabella, Bachert Claus, Baena-Cagnani Carlos, Bateman Eric, Bonini Sergio, Canonica Giorgio Walter, Carlsen Kai-Hakon, Demoly Pascal, Durham Stephen R., Enarson Donald, Fokkens Wytske J., Wijk Roy Gerth van, Horwarth Peter, Ivanova Nathalia A., Kemp James P., Klossek Jean-Michel, Lockey Richard F., Lund Valerie, Mackay Ian S., Malling Hans-Jrgen, Meltzer Eli O., Mygind Niels, Okuda Minoru, Pawankar Ruby, Price David, Scadding Glenis K., Simons F. Estelle R., Szczeklik Andrzej, Valovirta Erkka, Vignola Antonio M., Wang De-Yun, Warner John O., Weiss Kevin B.
Opracowanie edytorskie: Gawlewicz-Mroczka Agnieszka (Tł.), Mejza Filip (tł.), Świerczyńska Monika (tł.).
Źródło: Med. Prakt. 2002 (7) wyd. spec. s.1-263, il., tab., bibliogr. 2776 poz.
Sygnatura GBL: 312,921

Hasła klasyfikacyjne GBL:

pulmonologia

otorynolaryngologia

Typ dokumentu:

standard

Wskaźnik treści:

7/10

Tytuł oryginału: Reimplantation of ureters into the colon cap during sigmoidocystoplasty for treatment of vesicoureteric reflux associated with neurogenic bladder: long-term outcome.
Autorzy: Yamataka Atsuyuki, Wang Kun, Ohshiro Kiyohiko, Lane Geoffrey J., Gamal Alsagheer, Miyano Takeshi
Źródło: Surg. Childh. Int. 2002: 10 (1) s.6-9, il., bibliogr. 6 poz.
Sygnatura GBL: 313,040

Hasła klasyfikacyjne GBL:

pediatria

chirurgia

urologia

Typ dokumentu:

praca kliniczna

tytuł obcojęzyczny

Wskaźnik treści:

płeć żeńska

Streszczenie angielskie: The authors present the long-term outcome of reimplantation of ureters into the colon cap (RUCC) during sigmoidocystoplasty (SCP) for the treatment of vesicoureteric reflux (VUR) associated with neurogenic bladder. A retrospective review of thirteen patients with VUR associated with neurogenic bladder (24 ureters) that had RUCC during SCP at our institution was dne. Mean age at surgery was 10.9 yrs (range: 2.1 - 16.4 yrs). Mean follow-up period is 11.5 yrs (range: 5.3 - 16.3 yrs). Severrity of VUR was grade V in 4/24 ureters, grade IV in 12/24, grade III in 4/24, and grade II in 4/24. RUCC was performed into the taenia coli located in the anterior wall of the colon cap in 11/13 patients, and into the posterior wall of the colon cap in 2/13. The average length of the submucosal tunnel created during reimplantation was 23.0 mm. Excisional tapering of the ureter was performed in six ureters, and folding of the ureter in three. Postoperataive complications encountered were vesicoureteric junction stenosis, vesical calculi, and sponttaneous bladder perforation. Renal scarring that progressed to chronic renal faailure developed post-SCP in two patients. There has been no recurrence of VUR. RUCC during SCP is successful and should be actively considered when there is VUR associated with neurogenic bladder and the bladder wall is unsuitable for conventional reimplantation.

8/10

Tytuł oryginału: Lipoblastoma with a new chromosomal translocation.
Autorzy: Wang Huanghua, Greco Alba, Ahmed Atif
Źródło: Ann. Diagn. Paediatr. Pathol. 2002: 6 (3/4) s.131-134, il., tab., bibliogr. 21 poz.
Sygnatura GBL: 313,395

Hasła klasyfikacyjne GBL:

genetyka

onkologia

Typ dokumentu:

praca kazuistyczna

tytuł obcojęzyczny

Wskaźnik treści:

niemowlęta

Streszczenie angielskie: Lipoblastoma is a rare pediatric adipose tissue tumor that has to be distinguished from lipoma and myxoid liposarcoma. Cytogenetic studies can help in the differential diagnosis. Most lipoblastoma cases show cytogenetic alterations involving chromosome 8. We review the literature and report a case of a lipoblastoma in a 9-month old male infant with t(2;12)(q32;q15) translocation. According to our knowledge this is the first reported case of lipoblastoma with this translocation.

9/10

Tytuł oryginału: Intraperitoneal fluid accumulation induced by Clostridium perfringens alpha-toxin (Phospholipase C).
Autorzy: Maegawa Tsuneo, Wang Xingmin, Karasawa Tadahiro, Zuka Masahiko, Kita Hiroyuki, Nakamura Shinichi
Źródło: Acta Microbiol. Pol. 2002: 51 (4) s.387-389, tab., bibliogr. [10] poz.
Sygnatura GBL: 302,697

Hasła klasyfikacyjne GBL:

mikrobiologia

gastroenterologia

toksykologia

Typ dokumentu:

tytuł obcojęzyczny

praca doświadczalna

Wskaźnik treści:

myszy

Streszczenie angielskie: We report that the intraperitoneal injection of Clostridium perfringens alpha-toxin into mice induces ascites. This phenomenon was monitored by measuring fluid volume and analyzing hematologic data. The mouse toxicity test provides a simple and useful model for examining C. perfringens alpha-toxin-induced vascular permeability.

10/10

Tytuł oryginału: Chronic alpha1-adrenergic blockade improves hypertension and renal injury in L-NAME and low-renin L-NAME-DOCA hypertensive rats.
Autorzy: Wangesteen Rosemary, O'Valle Francisco, Moral Raimundo G. Del, Vargas Flix, Osuna Antonio
Źródło: Med. Sci. Monitor 2002: 8 (9) s.BR378-BR384, il., tab., bibliogr. 25 poz.
Sygnatura GBL: 313,278

Hasła klasyfikacyjne GBL:

farmacja

kardiologia

nefrologia

Typ dokumentu:

tytuł obcojęzyczny

praca doświadczalna

Wskaźnik treści: