Wynik wyszukiwania w bazie Polska Bibliografia Lekarska GBL

Zapytanie: WAKABAYASHI
Liczba odnalezionych rekordów: 3



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Tytuł oryginału: Dual effect of 2-methoxyestradiol on cell cycle events in human osteosarcoma 143B cells.
Autorzy: Gołębiewska Justyna, Rozwadowski Piotr, Spodnik Jan Henryk, Knap Narcyz, Wakabayashi Takashi, Woźniak Michał
Źródło: Acta Bioch. Pol. 2002: 49 (1) s.59-65, il., bibliogr. 25 poz.
Sygnatura GBL: 303,116

Hasła klasyfikacyjne GBL:
  • farmacja
  • onkologia

    Typ dokumentu:
  • praca związana ze zjazdem
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • in vitro

    Streszczenie angielskie: We have demonstrated for the first time that the steroid metabolite, 2-methoxyestradiol (2-ME) is a powerful growth inhibitor of human osteosarcoma 143 B cell line by pleiotropic mechanisms involving cell cycle arrest at two different points and apoptosis. The ability of 2-ME to inhibit cell cycle at the respective points has been found concentration dependent. 1 ćM 2-ME inhibited cell cycle at G1 phase while 10 ćM 2-ME caused G2/M cell cycle arrest. As a natural estrogen metabolite 2-ME is expected to perturb the stability of microtubules (MT) in vivo analogously to Taxol - the MT binding anticancer agent. Contrary to 2-ME, Taxol induced accumulation of osteosarcoma cells in G2/M phase of cell cycle only. The presented data strongly suggest two different mechanisms of cytotoxic action of 2-ME at the level of a single cell.

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    Tytuł oryginału: Co-existence of apoptotic and necrotic features within one single cell as a result of menadione treatment.
    Autorzy: Kamiński Marcin, Karbowski Mariusz, Miyazaki Yu, Kędzior Jakub, Spodnik Jan Henryk, Gil Aleksandra, Woźniak Michał, Wakabayashi Takashi
    Źródło: Folia Morphol. 2002: 61 (4) s.217-220, il., bibliogr. 13 poz.
    Sygnatura GBL: 301,720

    Hasła klasyfikacyjne GBL:
  • farmacja
  • onkologia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • in vitro

    Streszczenie angielskie: In the present study we examined the effects of menadione, a redox cycling agent, on structural changes of human osteosarcoma line 143B cells. It has been previosly reported that menadione can cause necrotic or apoptotic cell death in a concentration- depending manner. In our experimental model, cells were treated with 100 ćM menadione for 24 hours. Using electron microscopy technique cells carrying three kinds of morphological changes were detected: necrotic cells, apoptotic cells and those demonstrating a co-existence of apoptotic and necrotic features in one single cell.

    3/3

    Tytuł oryginału: Divergent effects of quinolinic aminoxyls on mitochondrial ultrastructure and localisation in osteosarcoma 143 B cells.
    Autorzy: Spodnik Jan Henryk, Kędzior Jakub, Gil Aleksandra, Woźniak Michał, Wakabayashi Takashi, Falcioni Giancarlo, Greci Lucedio
    Źródło: Folia Morphol. 2002: 61 (4) s.261-264, il., bibliogr. 18 poz.
    Sygnatura GBL: 301,720

    Hasła klasyfikacyjne GBL:
  • farmacja
  • onkologia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • in vitro

    Streszczenie angielskie: In the present study we have shown that quinolinic aromatic aminoxyls are very efficient in protecting lipids of endoplasmic reticulum membranes against hydroperoxide-induced oxidation. The efficacy of these aminoxyls as protectors of lipids was much higher than the water-soluble 4-OH-TEMPO. We have also shown that QAL causes distinct changes of the morphology of mitochondria: from filamentous to granular enlarged structure via the folding of the former. QAL induces also perinuclear clustering of mitochondria. C-QAL as well as 4-OH-TEMPO treated cells revealed filamentous and scattered pattern of mitochondria. Antioxidant activity of QAL as well as morphological changes of mitochondrial raise the possibility that this drug can affect cell physiology via changes of mitochondrial function.

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