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Tytuł oryginału: The diagnostics of recurrent gliomas using FDG-PET: still questionable?
Autorzy: Belohlavek Otakar, Klener Jan, Vymazal Josef, Dbaly Vladimir, Tovarys Frantisek
Źródło: Nucl. Med. Rev. 2002: 5 (2) s.127-130, il., tab., bibliogr. 18 poz.
Sygnatura GBL: 313,603

Hasła klasyfikacyjne GBL:
  • pediatria
  • onkologia
  • radiologia
  • neurologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dzieci 13-18 r.ż.
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: Background: For a number of years, FDG-PET was considered as a gold standard for the differential diagnosis of recurrent glioma and radionecrosis. Recently published papers haave introduced a waealth of scepticism into this area. The aim of this work is to specify the added value of FDG PET, as compared to MRI, in terms of diagnostics of recurrent gliomas in the clinical setting of the PET Centre Prague. Material and methods: MRI and FDG-PET were used to exmaine 29 patients for suspicious glioma recurrence, after 30 open neurosurgical operations or re-operations combined with chemo- and/or radiotherapy. The sensitivity, specificity and accuracy of both examinations were calculated with respect to their micromorphological findings (n = 28) or the clinical and radiological follow-up (n = 2). Results: MRI detected 23/24 tumour recurrences (sensitivity = 95.8 p.c.) and FDG PET only 15 of these (sensitivity = 62.5 p.c.) MRI specified only 3/6 radionecrotic lesions (specificity = 50.0 p.c.), while FDG PET identified 5/6 (specificity = 83.3 p.c.). Overall accuracy was 26/30 (86.7 p.c.) for MRI and 20/30 (66.7 p.c. ) for FDG PET. In the subgroup of MRI positive or equivocal findings (n = 229) FDG PET was clearly positive in 15 cases. High-grade glioma recurrence was subsequently confirmed in all of them. On the other hand negative or equivocal FDG PET was associated in 5/14 cases (35.7 p.c.) with radionecrosis, in 333/14 (21.4 p.c.) with low-grade glioma and in 6/14 (42.9 p.c.) with high-grade glioma. Conclusions: ...

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