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Tytuł oryginału: Plasma soluble L-selectin following cardiopulmonary bypass (CPB) in children: is it a marker of the postoperative course?
Autorzy: Dagan Ovdi, Prince Tal, Ben-Abraham Ron, Vidne Bernardo, Mishali David, Katz Yitshak, Keller Natan, Barzilay Zohar, Paret Gideon
Źródło: Med. Sci. Monitor 2002: 8 (7) s.CR467-CR472, il., tab., bibliogr. 27 poz.
Sygnatura GBL: 313,278

Hasła klasyfikacyjne GBL:
  • kardiologia
  • chirurgia
  • pediatria

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca kazuistyczna

    Wskaźnik treści:
  • ludzie
  • dzieci 2-5 r.ż.
  • dzieci 6-12 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: Background: There is increasing evidence that cytokine-inducible leukocyte-endothelial adhesion molecules are instrumental in the postoperative inflammatory response following cardiopulmonary bypass (CPB). L-selectin was shown to be one of those neutrophil-endothelial cell adhesion molecules. This study aimed to ivnestigate the relationship of teh soluble adhesion molecule, sL-selectin, and the postoperative course in children undergoing CPB. Material/Methods: To determine the time course of sL-selectin after CPB, serial blood samples of 9 children undergoing CPB were collected from the arterial line or from the bypass circuits preoperatively, on initiation of CPB and 1, 6, 12, 18, 24, and 48 hours postoperatively. Plasma was recovered immediately, aliqoted and frozedn at -70řC until use. Circulating sL-selectin molecules were measured witha sandwich enzyme-linked immunoabosrbent assay (ELISA) technique. there were significant changes in plasma levels of sL-selectin in patients following CPB, and these levels were associated with patient characteristics, operative variables and postoperative course. Low values of sL-selectin significantly correlated with inotropic support, low PRISM score, postoperative hypotension and fever. There was a significant association between the development of postoperative sepsis and low sL-selectin levels. No correlation was found between sL-selectin values and lactate concentration or neutrophil fount. Conclusions: Our results suggest a relation between CPB-induced mediators and both early and late clinical effects...

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