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VICTOROV
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Tytuł oryginału:
Changes in the distribution of sugar receptors in blood vessels and cell elements of rat brain caused by photochemically induced focal ischaemia.
Autorzy:
Szumańska
Grażyna,
Gadamski
Roman,
Victorov
Ilja V.,
Barskov
Igor V.,
Wojda
Renata,
Krzywicka
Jolanta
Źródło:
Folia Neuropathol. 2002: 40 (4) s.193-202, il., bibliogr. 30 poz.
Sygnatura GBL:
304,961
Hasła klasyfikacyjne GBL:
neurologia
Typ dokumentu:
praca doświadczalna
tytuł obcojęzyczny
Wskaźnik treści:
zwierzęta
szczury
płeć męska
in vitro
Streszczenie angielskie:
The lectin technique was applied to the histochemical studies of glycoconjugates comprising membranes of capillary endothelial cells and other cellular elements of the CNS. In the studies we used the following lectins: Concanavalian A (Con A), Bandeirea simplicifolia agglutinin (BS-I), Helix pomatia agglutinin (HPA), Ricinus communis agglutinin (RCA-120), Wheat germ agglutinin (WGA). We noticed changes in the localisation of the glycoconjugates, which are the results of cerebral ischaemia caused by focal irradiation of the left hemisphere of the brain after the previous intravenous injection of control animals with Rose bengal. The described changes seem to be the result of disturbances of the functioning of the blood-brain barrier, which was previously described (Gadamski et al. 2001). In this study, however, we have shown morphological and histochemical changes, which lead to the translocation of examined glycoconjugates within the appearing necrosis areas, arround them and in the regions significantly distant from them. This refers to neurones, glial cells and endothelia of brain vessels. So we have described a clear diminution of Con A and HPA-positive recpetors from neocortical and hippocampal neurones. The Con A receptors appeared however in morphologically changedd, contracted capillaries and HPA receptors in macrophages and reactive cells of necrosis areas. In these areas the BSI-I receptors also appeared and additionally labelled astrocytes in the hippocampuss and oligodendrocytes in the corpus callosum. The endothelial glycoconjugates visualised by RCA-120...
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