Wynik wyszukiwania w bazie Polska Bibliografia Lekarska GBL
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VERNEROVA
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2
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Tytuł oryginału:
Influence of losartan and enalapril on urinary excretion of 8-isoprostane in experimental nephrotic syndrome.
Autorzy:
Tesar
Vladimir,
Zima
Tomas,
Jirsa jr
Milan,
Crkovska
Jirina,
Stipek
Stanislav,
Vernerova
Zdena,
Serakova
Marketa
Źródło:
Med. Sci. Monitor 2002: 8 (2) s.BR69-BR74, il., tab., bibliogr. 31 poz.
Sygnatura GBL:
313,278
Hasła klasyfikacyjne GBL:
farmacja
nefrologia
Typ dokumentu:
badanie porównawcze
praca doświadczalna
tytuł obcojęzyczny
Wskaźnik treści:
zwierzęta
szczury
płeć żeńska
Streszczenie angielskie:
Background: The increased permeability of the glomerular capillary wall in adriamycin nephropathy may be mediated by incrased generation of free radicals, possibility also by the non-enzymatic production of isoprostanes induced by oxidative stress. ACE inhiitors and angiotensin II antagonists may reduce proteinuria, perhaps by decreasing intraglomerular pressure and increasing the selective permeability of the glomerular capillary wall. Material/Methods: We compared the effect of an ACE inhibitor, enalapril, and an angiotensin II atagonist, losartan, on total malodialdehyde in blood and the urinary excretion of certain eicosanodids and their metabolites (TxB2, 6-keto-PGF1a, bicyclo-PGE2 and 8-isoprostane) in experimental adriamycin-induced nephrotic syndrome in rats. Results: Increased proteinuria in adriamycin-treated rats was not prevented by losartan, but tended to be partly mitigated by enalapril. However, both losartan and enalapril prevented the adriamycin-induced increase of total MDA in serum, but urinary excretion of 8-isoprostane was increased in nephrotic rats treated by losartan compared to controls. The enalapril-induced increase in urinary excretion of bicyclo-PGE2 was possibly mediated by kinins. Proteiuria positively correlated with urinary excretion of 8-isoprostane, and proteinuric rats also had a significantly higher urinary excretion of 8-isoprostane than non-proteinuric rats. Conclusions: Proteinuria in the acute phase of adriamycine nephropathy may be dependent on free radical generation and the formation of 8-isoprostane. The mild anitproteinuric effect of enalapril, but not losartan, may suggest the contributory role of the inhibiton of kinin degradation in the antiproteinuric action of enalapril in this model of nephrotic syndrome.
2/2
Tytuł oryginału:
Multiple extrarenal complications of Wegener's granulomatosis.
Autorzy:
Rihova
Zuzana,
Merta
Miroslav,
Rysava
Romana,
Bezdicek
Petr,
Danzig
Vilem,
Gorican
Karel,
Lukas
Jindrich,
Skalicka
Pavlina,
Vernerova
Zdenka,
Tesar
Vladimir
Źródło:
Case Rep. Clin. Pract. Rev. 2002: 3 (1) s.1-4, il., tab., bibliogr. 11 poz.
Sygnatura GBL:
313,612
Typ dokumentu:
praca kazuistyczna
tytuł obcojęzyczny
Wskaźnik treści:
ludzie
dorośli 19-44 r.ż.
płeć żeńska
Streszczenie angielskie:
Background: We describe a sace of Wegener's Granulomatosis (WG), a diseases characterized by necrotizing granulomatous lesions and vasculitis of the upper and lower respiratory tract, necrotizing glomerulonephtitis with crescent formation and systemic vasculitis. Case report: The patients initially presented with a corneal perforation. In addition to the eye involvement, multiple other organ involvement was found during the course of the disease. The renal biopsy showed a pauciimmune necrotizing glomerulonephtitis with occlusive fibrocellular crescents, the interstitium was focally fibrotic with the skin vasculitis and arthralgias. Cardiac involvement included an acute myocardial infaraction and aortic valve vegetation, most likely caused by WG. Another complication during the initial presentation was a massive intestinal bleeding. The diagnosis of WG was established by renal, conjunctival and upper airway biopsies and by positive c-ANCA. The clinical and laborotory remission of the disease was achieved by combined immunosuppressive therapy with cyclophosphamide and corticosteroids. Later in the course of the disease the patient developed a subglottic stenosis, most probably due to reparative changes. Conclusions: In conclusion, this is a case of WG with multiple extrarenal complications, that had a grave clinical course.
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