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VASTYANNOV
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Tytuł oryginału:
TNF-ŕ in cerebral cortex and cerebellum is affected by amygdalar kindling but not by stimulation of cerebellum.
Autorzy:
Godlevsky
Leonid S.,
Shandra
Alexei A.,
Oleinik
Andrei A.,
Vastyannov
Rooslan S.,
Kostyushov
Vladimir V.,
Timchishin
Oleg L.
Źródło:
Pol. J. Pharmacol. 2002: 54 (6) s.655-660, tab., bibliogr. 25 poz.
Sygnatura GBL:
313,156
Hasła klasyfikacyjne GBL:
neurologia
Typ dokumentu:
praca doświadczalna
tytuł obcojęzyczny
Wskaźnik treści:
zwierzęta
szczury
płeć męska
Streszczenie angielskie:
One group of male Wistar rats was kindled by electrical stimulation (ES) of the amygdala, one group was sham operated, while other rats were stimulated in the paleocortex of the cerebellum. The kindled generalized clonic-tonic seizures were followed by a net increase of the tumor necrosis factor-ŕ (TNF-ŕ) content both in the cerebral cortex (from 34.7 ń 6.0 to 76.7 ń 6.9 pg/mg of wet brain tissue) and cerebellum (from 106.6 ń 17.7 to 193.8 ń 29.8 pg/mg of wet tissue) in comparison with the data from sham-operated animals. This effect was observed 24 h after the induction of the last kindled seizures. ES of the cerebellum (100 Hz) was not followed by any changes in TNF-ŕ content in the cortex and cerebellum. Morevover kindling was not followed by any changes in thiol/disulfide system, but ES of the paleocerebellum induced an increase in free thiol groups in the cortical tissue. It can be concluded that the increase in TNF0ŕ content in specific for the kindling process and that the antiepileptic effects of cerebellar ES might be realized via an intensification of antioxidative processes in the neural tissue.
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