Wynik wyszukiwania w bazie Polska Bibliografia Lekarska GBL
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VANDENBARK
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1
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Tytuł oryginału:
Estrogen inhibits systemic T cell expression of TNF-ŕ and recruitment of TNF-ŕ+ T cells and macrophages into the CNS of mice developing experimental encephalomyelitis.
Autorzy:
Ito
Atsushi,
Buenafe
Abigail C.,
Matejuk
Agata,
Zamora
Alex,
Silverman
Marc,
Dwyer
Jami,
Vandenbark
Arthur A.,
Offner
Halina
Źródło:
Clin. Immunol. 2002: 102 (3) s.275-282, il., tab., bibliogr. 40 poz.
Sygnatura GBL:
305,911
Hasła klasyfikacyjne GBL:
immunologia
farmacja
neurologia
Typ dokumentu:
praca doświadczalna
praca opublikowana za granicą
tytuł obcojęzyczny
Wskaźnik treści:
zwierzęta
myszy
Streszczenie angielskie:
Estrogen treatment has been found to have suppressive activity in several models of autoimmunity. To investigate the mechanism of 17á-estradiol (E2) suppression of experimental autoimmune encephalomyelitis, we evaluated E2 effects on TNF-ŕ experssion in the central nervous system (CNS) and spleen of C57BL/6 mice immunized with MOG 35-55/CFA. Kinetic analysis demonstrated that E2 treatment drastically decreased the recruitment of total inflammatory cells as well as TNF-ŕ+ macrophages and T cell into the CNS at disease onset. In contrast, E2 had only moderate effects on the erlatively high constitutive TNF-ŕ expression by resident CNS microglial cells. E2 treatment also had profound inhibitory effects on expression of TNF-ŕ by splenic CD4+ T cells, including those responsive to MOG 35-55 peptide. We propose that the mechanism of E2 protection may involve both systemic inhibition of TNF-ŕ expression and local (CNS) ercruitment of inflammatory cels, with modest effects on TNF-ŕ expression by resident CNS microglial cells.
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