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Tytuł oryginału: Type I interferons as immunoregulatory molecules; implications for therapy in experimental autoimmune uveoretinitis.
Autorzy: Mizuguchi Junichiro, Takeuchi Masaru, Usui Masahiko
Źródło: Arch. Immunol. Ther. Exp. 2002: 50 (4) s.243-254, bibliogr. 125 poz.
Sygnatura GBL: 304,223

Hasła klasyfikacyjne GBL:
  • immunologia
  • farmacja
  • okulistyka

    Typ dokumentu:
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • zwierzęta
  • szczury

    Streszczenie angielskie: Clinical trials have shown that type I interferon (IFN)-ŕ/á have some beneficial effects on organ-specific autoimmune diseases, such as Behcet's diseases and multiple sclerosis, although the precise mechanisms remain largely unresolved. T helper cells 1(Th1)-mediated autoimmune responses are involved in the initiation and/or progression of human uveitis, such as Behcet's disease. The animal model of experimental autoimmune uveoretinitis (EAU), characterized by a monophasic clinical course, has contributed to the understanding of the pathogenesis of human uveitis. Th1 producing IFN-ç induce EAU development, while Th2 producing IL-4/IL-10 prevent the disease. However, depending on the cytokine milieu, the pro-inflammatory cytokine IFN-ç may attenuate the autoimmune responses and anti-inflammatory cytokine IL-4 exacerbates it. Chemokines also play a crucial role in EAU development, which might be resolved by Th2-mediated immune responses. The administration of IFN-ŕ/á prevents EAU development, accompanied by a diminished production of IFN-ç/IL-10. Interestingly, however, IFN-ŕ/á also have some beneficial effects on patients with Th2-like phenotype in addition to Th1-like phenotype. Thus, the immuno-modulatory action of IFN-ŕ/á may be dependent on the context of cytokine combinant and/or their concentrations.

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