Wynik wyszukiwania w bazie Polska Bibliografia Lekarska GBL

Zapytanie: URBAŃSKA-RYŚ
Liczba odnalezionych rekordów: 3



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Tytuł oryginału: Aggressive primary plasma cell leukemia with skin manifestations, trisomy 8 and molecular oligoclonal features.
Autorzy: Robak Tadeusz, Urbańska-Ryś Halina, Bartkowiak Jacek, Strzelecka Bogusława, Biernat Wojciech, Kordek Radzisław
Źródło: Leuk. Lymphoma 2002: 43 (5) s.1067-1073, il., bibliogr. 40 poz.
Sygnatura GBL: 312,939

Hasła klasyfikacyjne GBL:
  • hematologia
  • onkologia
  • dermatologia i wenerologia

    Typ dokumentu:
  • praca kazuistyczna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • płeć męska

    Streszczenie angielskie: Plasma cell leukemia (PCL) is a very rare variant of multiple myeloma (MM) occuring in about 2 p.c. of newly diagnosed patients. Plasma cell leukemia may develop during the course of MM (secondary PCL) or it can occur without any prior sign of MM (primary PCL). We report a case of aggressive primary PCL with unusual clinical, cytogenetic and molecular features. A 36-year-old male patient was first seen because of fever and bone pain. On the skin of his chest, back, abdomen, and palpebras, there were nodular infiltrations resembling urticaria. White blood cell count was 10.8x10**9/1 with 41 p.c. plasmacytes. Bone marrow aspiration was hypercellular, 93.5 p.c. of cells were atypical plasmacytes and plasmablasts. The cytogenetic analysis of G-banded chromosomes in bone marrow cells yielded the trisomy 8. The skin biopsy specimen showed intensive infiltrates of uninucleated blastic cells similar to those found in the bone marrow. Immunophenotyping of bone marrow and skin neoplastic cells showed CD45+, CD45R0+, CD68+, CD38+ and cytoplasmic kappa light chain+. The neoplasic cells stained negatively for lambda light chain, CD3, CD20, CD30, EMA, CD15, CD34, CD56 and factor VIII. The pattern of IgL genes rearrangement in the bone marrow aspirate, peripheral blood mononuclear cells, and skin specimens was examined by PCR analysis. All studied specimens showed three different Igkappa gene configurations suggesting that the neoplastic cells originated as a result of oligoclonal lymphoproliferation process. The patient received two courses of VAD (vincristine, doxorubicin, dexamethasone)...


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    Tytuł oryginału: Acute lymphoblastic leukemia in adult first manifested as severe aplastic anemia - role of molecular analysis in correct diagnosis.
    Autorzy: Robak Tadeusz, Bartkowiak Jacek, Urbańska-Ryś Halina, Szmigielska-Kapłon Anna, Strzelecka Bogusława, Chojnowski Krzysztof
    Źródło: Leuk. Lymphoma 2002: 43 (5) s.1147-1152, il., bibliogr. 40 poz.
    Sygnatura GBL: 312,939

    Hasła klasyfikacyjne GBL:
  • genetyka
  • hematologia
  • onkologia

    Typ dokumentu:
  • praca kazuistyczna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • płeć męska

    Streszczenie angielskie: Aplastic anemia (AA) may sometimes precede the diagnosis of acute lymphoblastic leukemia (ALL) in children. Such presentation of ALL is externally rare in adults and until now only few such cases have been reported. We present a 40-year-old male with ALL common type, which developed 14 months after the diagnosis of severe AA, successfully treated with corticosteroids. ALL was treated with standard induction chemotherapy but remission has not been achieved. The patient died 6 weeks after the diagnosis of ALL because of central nervous system bleeding. The pattern of IgH gene rearrangement analyzed with PCR method in bone marrow from the period of AA diagnosis and in peripheral blood mononuclear cells from ALL diagnosis showed two different monoclonal IgH configurations as the results of biallelic monoclonal rearrangement of IgH genes. The observed bands in both specimens were identical and indicated that leukemic cells originated from B-cell progenitor were also present in the bone marrow when AA was diagnosed. We suggest that molecular analysis of monoclonality in patients with AA may be important for proper selection of the rare cases of ALL first presenting as marrow aplasia.


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    Tytuł oryginału: Lymphoplasmacytic lymphoma with monoclonal gammopathy-related pseudo-gaucher cell infiltration in bone marrow and spleen-diagnostic and therapeutic dilemmas.
    Autorzy: Robak Tadeusz, Urbańska-Ryś Halina, Jerzmanowski Piotr, Bartkowiak Jacek, Liberski Paweł, Kordek Radzisław
    Źródło: Leuk. Lymphoma 2002: 43 (12) s.2343-2350, il., bibliogr. 36 poz.
    Sygnatura GBL: 312,939

    Hasła klasyfikacyjne GBL:
  • hematologia
  • onkologia

    Typ dokumentu:
  • praca kazuistyczna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 45-64 r.ż.
  • płeć męska

    Streszczenie angielskie: Gaucher-like cells have occasionally been described in various haematological malignancies including Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma (MM) and chronic myelogenous leukemia (CML). A special type of this phenomenon is crystal-storing histocytosis or the so-called pseudo-pseudo Gaucher cells (PPGC) in which crystalline protein storage in macrophages is induced by paraproteinemia. Here we describe a 54-year-old man with an initial suspicion of Gaucher disease and monoclonal IgA gammopathy in whom a correct diagnosis of lymphoplasmacytic lymphoma (LPL) with massive infiltration of bone marrow and spleen by PPGC was confirmed by immunological, ultrastructural and molecular characterisation. The activity of leukocyte beta-glucocerebrosidase was only slightly elevated (7.3 nmol/mg protein/1h) which ruled out the diagnosis of classic Gaucher's disease. The patient received two courses of CHOP without improvement and anti-CD20 monoclonal antibody (rituximab) with only temporary stabilisation. Subsequently, he underwent splenectomy because of prolonged severe pancytopenia and a suspicion of hypersplenism. After splenectomy significant haematological improvement was observed. Following anti-CD20 therapy, changes in immunoprofile and morphology of tumour cells were evident. Before treatment the population of LPL was more divergent, with expression of LCA, CD20, CD38 and CD138. However, after the treatment, there were more mature plasma cells which no longer expressed CD20 antigen-this picture was more consistent with the diagnosis of plasma cell myeloma...

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