Wynik wyszukiwania w bazie Polska Bibliografia Lekarska GBL

Zapytanie: UCHIDA
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Tytuł oryginału: Comparison of motor reactivity of the colonic muscularis mucosae isolated from human, guinea pig and rat in vitro.
Autorzy: Kamikawa Yuichiro, Shibukawa Asako, Uchida Kohsuke, Sakuma Atsushi, Kubota Kei-ichi, Ohno Yasuo
Źródło: Pol. J. Pharmacol. 2002: 54 (3) s.261-266, il., tab., bibliogr. 30 poz.
Sygnatura GBL: 313,156

Hasła klasyfikacyjne GBL:
  • farmacja

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • zwierzęta
  • szczury
  • Świnki morskie
  • in vitro

    Streszczenie angielskie: We have compared the reactivity to spasmogens of longitudinal muscularis mucoase isolated from the human, guinea pig and rat colon in vitro. The muscularis mucosae isolated from the human distal colon responded with a sustained contractions to carbachol (10 nM - 30 ćM), in a concentration-dependent manner, and the maximum contraction was comparable to that with potassium concentration (100 mM). Among several spasmogens, neurokinin A was the most potent with the following order of potency: carbachol, prostaglandin F2ŕ an dacetylcholine. Histamine, 5-hydroxytryptamine and bradykinin did not produce a recognizable contraction of this tissue. The muscularis mucosae isolated from the guinea pig distal colon demonstrated a concentration-dependent contraction in response to neurokinin A, carbachol, histamine and acetylcholine, but not to prostaglandin F2ŕ or 5-hydroxytryptamine, and the maximum contraction was obtained with histamine. The muscularis mucoase from the rat distal colon was very sensitive to neurokinin A and bradykinin, less to carbachol and acetylcholine, and not at all sensitive to histamine, 5-hydroxytryptamine and prostaglandin F2ŕ. It is concluded that the colonic muscularis mucoase respond to pharmacological agents in a species-different manner.

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    Tytuł oryginału: Left ventricle simulator for surgeons support.
    Autorzy: Umezu Mitsuo, Arita Makoto, Iwasaki Kiyotaka, Shiraishi Yasuyuki, Tono Sumihiro, Uchida Koji
    Źródło: Biocybern. Biomed. Eng. 2002: 22 (4) s.47-53, il., bibliogr. 2 poz.
    Sygnatura GBL: 306,224

    Hasła klasyfikacyjne GBL:
  • kardiologia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca doświadczalna

    Streszczenie angielskie: The authors have been developing various types of mock circulatory systems to evaluate a performance of artificial organs. Among several attempts, it was indicated that a stimulation of the mitral valve region was very difficult due to a complicated shape and movement of the valve. In this paper a new trial to install a porcine valve into the mock circulatory systemis introduced. A fresh porcine valve with papillary muscles and chordae was fixed into the mitral position of the modified Windkessel-type mock circulatory system. To allow direct 3-D observation of the mitral annulus, a digital video camera and a laser displacement sensor were employed. A circulation was generated by a pneumatically-driven artificial ventricle. When a normal circulatory condition (pump rate: 70BPM, Flow: 3L/min) was selected, similar opening and closing motion to the natural mitral valve could be reproduced. Moreover, a diseases condition was made by shifting a position of papillary muscles. After this procedure, an abnormal movement, such as significant leakage, could also be reproduced.

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