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Tytuł oryginału: The effect of perendoscopic sclerosing agent injection in Forrest's II ulcers - a pilot study from Turkey.
Autorzy: Saruc Murat, Ozden Nuri, Kucukmetin Nurten, Tuzcuoglu Isil, Yuceyar Hakan
Źródło: Med. Sci. Monitor 2002: 8 (11) s.CR735-CR739, tab., bibliogr. 21 poz.
Sygnatura GBL: 313,278

Hasła klasyfikacyjne GBL:
  • gastroenterologia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca kliniczna
  • badanie porównawcze

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: Bakcground: We aimed to clarify the outcome of perendoscopic prophylactic injection of sclerosing agent in Forrest's II ulcers. Material/Methods: Patients with upper gastrointestinal bleeding in last 6 hours were performed emergency endoscopy and were enrolled. The patients in group-1 were performed prophylactic injection therapy with 1 p.c. aethoxyclerol and then given medical treatmetn with intravenous 40 mg omeprazole twice a day and somatostatin infusion at the dose of 6 mg/day during 3 days. Group-2 patients were only given medical treatment with same agents and at same doses without having any perendoscopic therapy. Results: There were 32 pateitns in group-1 and 20 in group-2. In emergency endoscopy, 20 (62.5 p.c.) patietns had IIa ulcers and 12 (37.5 p.c.) patients had IIb ulcers in group-1. These patients underwent prophylactic perendoscopic hemostasis by 1 p.c. aethoxysclerol in addition to medical treatment. Early rebleeding occurred in 9 (28.1 p.c.) patients of group-1 and 3 (15 p.c.) in group-2 (p 0.001). At the endoscopic control after 48 hours 13 (40.6 p.c.) patients in the group-1 and 15 (75 p.c.) patients in group-2 showed improved local ulcer stigmata (p 0.001). The numbers of blood units transfused were lower in the group-2 (p = 0.002). THe hospital stay was longer in group-1 (p = 0.01). In the group-1, more endoscopic intervention was needed. Any death and the need for surgical intervention did not occurred in any groups. Conclusion: According to our resutls; the indication of perendoscopic prophylactic injection of sclreosing agent in non-bleeding ulcers with high risk of rebleeding must be reviewed by large population based, prospective, randomized trials.

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