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Tytuł oryginału: Long-term therapy with recombinant human erythropoietin decreases percentage of CD152+ lymphocytes in primary glomerulonephritis haemodialysis patients.
Autorzy: Trzonkowski Piotr, Myśliwska Jolanta, Dębska-Ślizień Alicja, Bryl Ewa, Rachoń Dominik, Myśliwski Andrzej, Rutkowski Bolesław
Źródło: Nephrol. Dial. Transplant. 2002: 17 (6) s.1070-1080, il., tab., bibliogr. 25 poz.
Sygnatura GBL: 312,872

Hasła klasyfikacyjne GBL:
  • immunologia
  • farmacja
  • nefrologia

    Typ dokumentu:
  • praca kliniczna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.

    Streszczenie angielskie: Bacground. Recombinant human erythropoietin (rHuEpo) may affect the human immune system. The aim of the study was to examine changes in CD4+ and CD8+ T-cell subpopulations, the expression of the inhibitory molecule, CD152 on T lymphocytes and the levels of interleukins (IL), 2, 6, 10, 12 and tumour necrosis factor ŕ )TNFŕ) in primary glomerulonephritis chronic haemodialysis (HD) patients before and under rHuEpo treatment. Methods. Expression of T-cell surface molecules was measured in 14 HD patients ex vivo by flow cytometry of lymphocytes sampled from peripheral blood and in viutro using whole blood cell cultures stimulated either with phytohaemagglutinin (PHA) or with physiological as well as non-physiological does or rHuEpo. The concenrations of the cytokines were measured in the supernatans from non-or PHA-stimulated cultures using bioassays (IL2, IL6, TNFŕ) or ELISA test (IL10, IL12). Results. Compared with findings before the start of rHuEpotherapy the CD4+/CD8+ ratio increased after 1 year of follow-up, whereas the percentage of CD152+ peripheral blood lymphocytes decreased. The increase of the CD4+/CD8+ rtio was dependent on a decrease of the percentage of CD8+ cells. The decrease of CD152+ population affected mainly CD8+ CD152+ cells. All these effects became apparent after 6 months of rHuEpo treatment. In vitro stimulation of whole blood cultures revealed that the addition of PHA up-regulated the percentage of CD152+ lymphocytes, while physiological concentrations of rHuEpo decreased the percentage of CD8+ 152+ T cells...

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