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Zapytanie: TIMMS
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Tytuł oryginału: Plasma tissue inhibitor of metalloproteinases-1 and transforming growth factor á1 - possible non-invasive biomarkers of hepatic fibrosis in patients with chronic B and C hepatitis.
Autorzy: Flisiak Robert, Maxwell Paul, Prokopowicz Danuta, Timms Peter M., Panasiuk Anatol
Źródło: Hepatogastroenterology 2002: 49 (47) s.1369-1372, il., tab., bibliogr. 22 poz.
Sygnatura GBL: 304,355

Hasła klasyfikacyjne GBL:
  • gastroenterologia

    Typ dokumentu:
  • praca kliniczna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny
  • badanie porównawcze

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: Background/Aims: The role of transforming growth factor-á1 (TGF-á1) in liver fibrosis is in part related to impairment of extracellular matrix breakdown by stimulation of tissue inhibitor of metalloproteinases-1 (TIMP-1) gene. The aim of he study was to evaluate association between TGF-á1 and TIMP-1 in relation to liver injury in chronic viral hepatitis N and C. Methodology: Association between plasma TGF-á1 and TIMP-1 was evaluated in 28 consecutive patients undergoing kiver biopsy for chronic viral hepatitis B and C (CH-B, CH-C) and these tests were correlated with hepatic fibrosis, inflammation and liver function tests. Moreover carboxyterminal cross-linked telopeptide of type 1 procollagen (ICTP) and carboxyterminal propeptide of type 1 collagen (PICP) were also measured for assessment of extracellular matrix breakdown or synthesis, respectively. Results: Chronic viral hepatitis B and C resulted in a significant increase in plasma TIMP-1 levels but not TGF-á1. Among biochemical markers of liver injury, significant correlation with TGF-á1 and TIMP-1 was demonstrated in respect to aminotransferase activities in both groups. TIMP-1 showed significant correlation with ICTP levels in both CH-B (r = 0.59) and CH-C (r = 0.62), whereas TGF-á1 was correlated with ICTP only in CH-C patients (r = 0.75). PICP did not demonstrate any corelation with either TGF-á1 or TIMP-1. Hepatic fibrosis, but not inflammation, correlated significantly with TGF-á1 (CH-B: r = 0.73; CH-C: r = 0.79) and TIMP-1 (CH-B: r = 0.66; CH-C r = 0.71) in both groups and there was a significant...

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