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Second inter-laboratory study comparing endotoxin assay results from cotton dust.
David T. W.,
Ann. Agric. Environ. Med. 2002: 9 (1) s.49-53, il., tab., bibliogr. 17 poz.
Hasła klasyfikacyjne GBL:
Previously, a large two-part inter-laboratory round robin endotoxin assay study was completed. This first study showed that when cotton dust samples, which are practically identical, are assayed for endotoxin that the intra-laboratory results had a very small variation while intra-laboratory results of the sample had a very high variation. In the first part of the study, each laboratory results of the sample had a very high variation. In the first part of the study, each laboratory followed its own in-house assay protocol; but in the second part of the study, when the extraction protocol was standardized, the inter-laboratory results showed a lower variation, which suggested that with further standardization, further reduction of differences between laboratories might be achieved in order that results between laboratories would become more comparable. The results stimulated interest in extending the study to include cotton dust with two levels of endotoxin, standardization of the extraction proteocol, and using the same assay kit from the same production lot. The results of this second round robin endotoxin assay study indicate that differences between laboratories are still high, but most of the laboratories could discern the cotton dusts with the different levels of endotoxin.
Credibility of problem-solving therapy and medication for the treatment of depression among primary care patients.
Med. Sci. Monitor 2002: 8 (3) s.CR193-CR196, tab., bibliogr. 12 poz.
Hasła klasyfikacyjne GBL:
psychiatria i psychologia
dorośli 19-44 r.ż.
dorośli 45-64 r.ż.
Background: Patient beliefs in the effectiveness of treatment may have an importan influence on treatment outcome. Material/Methods: Associations between patient beliefs in the credibility of treatment and outcome were explored in a randomised controlled trial of major depression in primary care (n = 155). The four treatments were antidepressant medication given by research general practitioner, problem solving treatment given by research general practitioner or research practice nurse over 12 weeks or a combination of problem solving treatment and antidepressant medication. Patietns' belief in the credibility of treatment was assessed using a brief Credibility Scale, that was completed following randomisation and after tretment. Depression outcome was measured at 6, 12 and 52 weeks using the Hamilton Rating Scale for depression, and the Beck depression inventory. Results: Pre-treatment, medication treatment was associated with a higher certainty of recovery than was problem-solving treatment from the nurse (p = 0.018). Post-treatment, medication and combination treatment were seen as more logical than problem-solving treatment from the nurse (p 0.03). Post-treatment medication had higher certainty of recovery and was more highly recommended to a friend. Linear regression demonstrated that the depression outcome measures were not associated with either pre- or post-treatment credibility. Conclusions: Patietns found all four treatments highly credible following their initial explanation. There was a significant difference both pre- and post-treatment in favour of patients finding treatment involving medication more credible than problem-solving from a nurse. Pre- and post-treatment scores of credibility were not associated with outcome.
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