Wynik wyszukiwania w bazie Polska Bibliografia Lekarska GBL

Zapytanie: THOMAS
Liczba odnalezionych rekordów: 3

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Tytuł oryginału: Modulation of the susceptibility of intestinal bacteria to bacteriophages in response to Ag43 phase variation - a hypothesis.
Autorzy: Węgrzyn Grzegorz, Thomas Mark S.
Źródło: Med. Sci. Monitor 2002: 8 (6) s.HY15-HY18, bibliogr. 38 poz.
Sygnatura GBL: 313,278

Hasła klasyfikacyjne GBL:
  • mikrobiologia

    Typ dokumentu:
  • tytuł obcojęzyczny

    Streszczenie angielskie: Escherichia coli is a Gram-negative bacterium which colonises the intestinal tract of man and other animals. In addition to being a part of the normal bacterial flora of the human intestine, there are a number of enteropathogenic strains of E. coli which cause infections ranging in consequence from diarrhoea to colitis. Antigen 43 (Ag43) is the major phase-variabale protein in the outer membrane of E. coli. One benefit for bacteria resulting from phase variation of surface antigns is usually ascribed to evasion of host defences. However, results of recent studies indicate that infection of E. coli by different bacteriophages is inhibited in the presence of certain bile salts and carbohydrates (components present in the human intestine but absent in standard bacteriological media) when cells are in the "OFF" state for production of Ag43. The inhibition of bacteriophage development was found to be due to a significant impairment in the process of phage adsorption and evidence was presented for the binding of phage to Ag43. Here we present a hypothesis that in the case of Ag43, phase-variation might benefit the host bacterium by modulating the susceptibility to phage infection in the gut. If this hypothesis is true, it may have important implications not only for basic research but also for development of bacteriophage therapy, a re-discovered method of treatment of patients with infectious diseases.


    Tytuł oryginału: Effects of immunomodulators on acute Trypanosoma cruzi infection in mice.
    Autorzy: Oz Helieh S., Hughes Walter T., Thomas Elaine K., McClain Craig J.
    Źródło: Med. Sci. Monitor 2002: 8 (6) s.BR208-BR211, il., tab., bibliogr. 14 poz.
    Sygnatura GBL: 313,278

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • myszy

    Streszczenie angielskie: Patients who recover from acute trypanosomiasis may succumb to chronic Chagas' disease later in life due to age related immunosuppression, immune system disorders such as AIDS, or during periods of immunosuppressive therapy for organ transplantation. In this study, effects of immunomodultors with diverse properties were examined on the course of an acute and lethal Trypanosoma cruzi infection. ICR (Swiss) mice inoculated with Tulahuen (lethal) strain of T. cruzi were treated with 6 different immunomodulators and the course of infection was studied. Tacrolimus (FK-506) and dexamethasone increased parasitemia in mice when compared to infected untreated animals. Mycophenolate mofetil (RS-61443) ana recombinant interleukin-15 (IL-15) treatment decreased the number of parasites but had no effect on animal survival. In contrast, compound L-685-818 (tacrolius analog) and CD40 ligand (CD40L), provided protection against lethal infection. Mice that survived initial infection were all protected against reinfection. This study demonstrates the dangers of immunosuppression with tacrolimus and dexamethasone in T. cruzi infected subjects. While mycophenolate did not exacerbate the infection, our data suggest potential therapeutic applications for L-685-818 and CD40 ligand in trypanosomiasis.


    Tytuł oryginału: Ilustrowany podręcznik chorób alergicznych
    Autorzy: Grevers Gerhard, R”cken Martin, Behr Jrgen, Bischoff Stephan C., Krause Eike, Riedl-Seifert Roland, Ritter Christoph von, Sturm Cordula, Thomas Peter, Thurau Stephan, Zippel Stefan
    Opracowanie edytorskie: Panaszek Bernard (red. i tł.), Nittner-Marszalska Marita (tł.).
    Źródło: - Wrocław, Wydaw. Medyczne Urban and Partner 2002, IX, [1], 243 s. : il., tab., 21 cm. - Tyt. oryg. Taschenatlas der Allergologie
    Sygnatura GBL: 736,218

    Hasła klasyfikacyjne GBL:
  • immunologia

    Wskaźnik treści:
  • ludzie

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