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Tytuł oryginału: Annals of Diagnostic Paediatric Pathology
Tytuł angielski: Cushing's disease in a 5 months infant due to a basophilic microadenoma of the pituitary gland.
Autorzy: Ferraz Maria Lucia da Fonseca, Oliveira Gamaniel de, Almeida Joao, Reis Marlene Antonia dos, Teixeira Vincente de Paula Antunes, Castro Eumenia Costa da Cunha
Źródło: Ann. Diagn. Paediatr. Pathol. 2002: 6 (3/4) s.141-143, il., bibliogr. 29 poz.
Sygnatura GBL: 313,395

Hasła klasyfikacyjne GBL:
  • endokrynologia
  • onkologia

    Typ dokumentu:
  • praca kazuistyczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • niemowlęta

    Streszczenie angielskie: We report a five-month old girl with classical clinical features of Cushing's syndrome. Histological findings showed a basophilic microadenoma of the pituitary gland, leading to a diagnosis of Cushing disease (CD). The child died because of untreatable septic shock. The importance of the present report resides in the age of the child at the diagnosis. CD is the most often diagnosed in children older than seven years, and our patient was only five months old when we detected the pituitary adenoma, this was the earliest case diagnosed thus far. Cushing's syndrome in pediatric patients has been rarely reported and most of the cases are due to functioning adrenal tumour, usually a malignant carcinoma but occasionally a benign adenoma. The present case shows that the pituitary of this patients should be investigated with important implications in terms of therapeutic approaches such as radiotherapy of the pituitary, which can cure the patient when treatment is started as soon as possible.

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