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Tytuł oryginału: Mifepristone (RU-486) impairs post-surgical wound healing of the larynx.
Autorzy: Tcacencu Ion
Źródło: Med. Sci. Monitor 2002: 8 (10) s.BR397-BR400, il., tab., bibliogr. 23 poz.
Sygnatura GBL: 313,278

Hasła klasyfikacyjne GBL:
  • toksykologia
  • chirurgia
  • otorynolaryngologia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • króliki
  • płeć męska

    Streszczenie angielskie: Background: The purpose of this study was to examine how RU486 (mifepristone), a glucocorticoid antagonist, affects the regeneration process in a rabbit laryngeal wound-healing model. Material/Methods: Eight rabbits underwent a cricoid-split operation with collagen sponge insertion. The animals were classified randomly into two groups (4 animals in each group): the RU486-treated group, with local administration of 3 mg RU486, and the control gorup, which was sham treated. The specimens were harvested seven days after surgery. Histomorphometric analysis was performed to evaluate the healing pattern of the layrnx wound. Results: Respiratory epithelium regeneration was delayed in the RU486-treated group. The proliferation of granulation tissue was also increased. Polyps were detected in 3 specimens from this group. No obvious differences with regard to inflammatory cell infiltration were found. Conclusion: RU486 impairs post-surgical wound healing of the larynx by increasing the presence of granulation tissue and polyps, and appears to delay re-epithelialization.

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