Wynik wyszukiwania w bazie Polska Bibliografia Lekarska GBL

Zapytanie: TASHTOUSH
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Tytuł oryginału: Synthesis, antibacterial, antifungal and genotoxic activity of bis-1,3,4-oxadiazole derivatives.
Autorzy: Maslat Ahmed O., Abussaud Mahmud, Tashtoush Hasan, AL-Talib Mahmoud
Źródło: Pol. J. Pharmacol. 2002: 54 (1) s.55-59, il., tab., bibliogr. 30 poz.
Sygnatura GBL: 313,156

Hasła klasyfikacyjne GBL:
  • farmacja

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Streszczenie angielskie: In the present investigation, four 1,3,4-bis-oxadiazole derivatives were synthesized as potential antimicrobial agents. The compounds are: 5,5'-dimercapto-bis-[1,3,4-oxadiazol-2-yl]propane (2a), 5,5'-dimercapto-bis-[1,3,4-oxadiazol-2-yl]butane (2b), 5,5'-dimercapto-bis-[1,3,4-oxadiazol-2-yl]octane (2c) and 5,5'-dibenzylthio-bis-[1,3,4-oxadiazol-2-yl]butane (3). The above newly synthesized compounds were investigated for their antibacterial, antifungal and mutagenic activities. The results of the biological activities revealed that the compounds 2a-c exhibited both antibacterial and antifungal activities against S. aureuss and B. subtilis. Compound 2a also showed activity against P. aeureoginosa. All the above compounds and compound 3 exhibited activity against C. albicans. Genotoxic studies showed that compound 2a had a weak base pair substitution mutagenicity but none of them exhibited a frameshift mutagenic action using Ames test.

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    Tytuł oryginału: Azathioprine-induced fatal macrocytic anemia in rabbits.
    Autorzy: Al-Safi Saafan, Tashtoush Bassam, Abdul-Razzak Khalid
    Źródło: Pol. J. Pharmacol. 2002: 54 (5) s.513-516, tab., bibliogr. 40 poz.
    Sygnatura GBL: 313,156

    Hasła klasyfikacyjne GBL:
  • farmacja

    Typ dokumentu:
  • praca doświadczalna
  • komunikat
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • króliki

    Streszczenie angielskie: Azathioprine (AZA) is used clinically sometimes at high doses for short-term therapy to treat acute rejection of kidney allograft or to desensitize hypersensitive patients to it. The delayed consequences of this approach had not been well investigated. Therefore, in this study we have investigated the delayed consequences of high-dose short-term AZA administration in rabbits. Our results showed that oral administraton of AZA (10 mg/kg/day) to rabbits for two weeks induced reversible thrombocytosis and delayed fatal macrocytic anemia. Moreover, neither the hemoglobin level nor the the white blood cell count was affected by AZA. The solvent of AZA had no effect onblood cell counts and hemoglobin levels. We can conclude that although high-dose AZA therapy may not induce immediate and significant changes in blood picture, delayed fatal macrocytosis may occur.

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