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Tytuł oryginału: Pathology of endocrine pancreas in persistent hyperinsulinemic hypoglycemia in children - practical diagnostic considerations.
Autorzy: Pronicki Maciej, Grajkowska Wiesława, Iwanicka Katarzyna, Szymańska-Dębińska Tamara, Taybert Joanna, Drewniak Tomasz
Źródło: Ann. Diagn. Paediatr. Pathol. 2002: 6 (3/4) s.103-108, il., tab., bibliogr. 41 poz.
Sygnatura GBL: 313,395

Hasła klasyfikacyjne GBL:
  • pediatria
  • endokrynologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • noworodki
  • niemowlęta
  • dzieci 2-5 r.ż.
  • dzieci 6-12 r.ż.
  • dzieci 13-18 r.ż.

    Streszczenie angielskie: Persistent hyperinsulinemic hypoglicemia (PHH) is connected with many different histopathological lesions of endocrine pancreas. Their character may be both cytological and architectural. The previously widely used term nesidioblastosis caused much confusion because of lack of strict criteria. At present most authors recognise two basic forms: focal and diffuse. This concept provides the basis for possible effectiveness of limited surgery with the aid of intraoperative frozen sections. In many patients defined molecular abnormalities related to hyperfunction and proliferation of beta cells were reported. The aim of the study was to reassess histopathological slides from resection specimens of the pancreas from 70 children with PHH aged 1 week to 16 years treated in our institution. Multiple blocks were step-sectioned and stained routinely as well as immunohistochemically to visualise all 4 types of endocrine cells. Age matched control group consisted of 40 pancreata obtained during autopsy from children who died due to endocrine unrelated events. Ten possible different abnormal features of endocrine cell population were recorded. The following different patterns of lesions were found: 1.adenoma; 2.focal adenomatosis; 3.diffuse florid "nesidiodysplasia" type; 4.diffuse with minimally hypertrophic endocrine nuclei; 5. diffuse only with distinct hypertrophic nuclei; 6.diffuse borderline; 7.normal histology. We concluded that focal lesions underlying PHH in children are clearly defined pathologically, and have reliable morphological criteria...

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