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SZPILEWSKA
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Tytuł oryginału:
Comparison of the Ames test and a newly developed assay for detection of mutagenic pollution of marine environments.
Autorzy:
Czyż
Agata,
Szpilewska
Hanna,
Dutkiewicz
Rafał,
Kowalska
Wioletta,
Biniewska-Godlewska
Anna,
Węgrzyn
Grzegorz
Źródło:
Mutat. Res 2002: 519 (1/2) s.67-74, il., tab., bibliogr. 17 poz.
Sygnatura GBL:
304,952
Hasła klasyfikacyjne GBL:
ochrona środowiska
genetyka
Typ dokumentu:
praca epidemiologiczna
praca opublikowana za granicą
tytuł obcojęzyczny
Streszczenie angielskie:
A new assay for detection of mutagenic pollution of marine environments, based on the use of a series of genetically modified Vibrio harvbeyi strains, was developed recently. Here, we compared this assay with a commonly used Ames test, employing mutants of Salmonella enterica serovar Typhimurium. We found that survival of S. enterica serovar Typhimurium inartificial marine water and in different samples of marine water is dramatically reduced relative to that of V. harveyi strains. This indicates that V. harveyi strains are significantly more useful in testing samples of marine water. Moreover, sensitivity of both assays was compared. We found that using the V. harveyi assay it is possible to detect significantly (from a few to several times) lower concentrations of typical chemical mutagents than employing the Ames test. Although the higher sensitivity of the V. harveyi test relative to the Ames assay may be of minor importance when testing mutagenicity of certain chemicals in their pure from under laboratory conditions, this feature is very important in testing samples of marine water. Therefore, we assume that the V. harveyi assay may be an adequate test for detection of mutagenic pollution of marine environments.
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