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SULOCHANA
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Tytuł oryginału:
Effect of oral supplementation of free amino acids in type 2 diabetic patients - a pilot clinical trial.
Autorzy:
Sulochana
Konerirajapuram Natarajan,
Lakshmi
Soundarajan,
Punitham
Ranganathan,
Arokiasamy
Tharigopala,
Sukumar
Baluswamy,
Ramakrishnan
Sivaramakrishna
Źródło:
Med. Sci. Monitor 2002: 8 (3) s.CR131-CR137, il., tab., bibliogr. 33 poz.
Sygnatura GBL:
313,278
Hasła klasyfikacyjne GBL:
endokrynologia
Typ dokumentu:
praca kliniczna
tytuł obcojęzyczny
badanie porównawcze
Wskaźnik treści:
ludzie
płeć męska
płeć żeńska
Streszczenie angielskie:
Background: Oral amino acid intake reduces plasma glucose in Streptozotocin-induced diabetic rats. This study examined the effect of oral amino acid supplementation in patients with type 2 diabetes mellitus (DM). Material/Methods: A double blind pilot clinical trail was conducted for a period of 2 moonths on 77 subjects with type 2 DM. Subjects of both sexes, ages 30-60, were included in the trial. All were receiving oral antidiabetic tablets. They were divided into groups on the basis of oral supplementation: (A) lysine, (B) essential amino acids, (C) amino acids and vitamins (fat and water-soluble), and (D) calcium phosphate (control). The subjects were periodically examined for fasting and post-prandial plasma glucose, fasting and post-prandial immunoreactive insulin, plasma amino acids, glycosylated haemoglobin (HbA1c), proteins and albumin in serium, urea and creatinine in plasma and sugar, and proteins and ketones in urine. Results: The results revealed a significant decrease in PP plasma glucose (P 0.05) in group B when compared to group s C and D after 45 days. Plasma Arginine was increased in group C from 3.84 to 9.24 mg/dl. There were no statistically significant changes seen in other parameters between groups and visits. Conclusions: Oral supplementation with amino acids for patients with type 2 DM appears to decrease PP plasma glucose without any change in plasma insulin levels, perhaps due to improved insulin sensitivity. However, the long term effects of amino acids need further study.
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