Wynik wyszukiwania w bazie Polska Bibliografia Lekarska GBL
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SUCAJTYS
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Tytuł oryginału:
Increased rate of cholesterologenesis - a possible cause of hypercholesterolemia in experimental chronic renal failure in rats.
Autorzy:
Szołkiewicz
M[arek],
Sucajtys
E.,
Chmielewski
M.,
Wołyniec
W.,
Rutkowski
P.,
Bogusławski
W.,
Świerczyński
J.,
Rutkowski
B[olesław]
Źródło:
Horm. Metab. Res. 2002: 34 (5) s.234-237, il., tab., bibliogr. 19 poz.
Sygnatura GBL:
312,226
Hasła klasyfikacyjne GBL:
genetyka
nefrologia
Typ dokumentu:
praca doświadczalna
praca opublikowana za granicą
tytuł obcojęzyczny
Wskaźnik treści:
zwierzęta
szczury
płeć męska
Streszczenie angielskie:
Hipercholesterolemia plays an important role in the lipid abnormalities in chronic renal failure (CRF). It is thourght to contribute to both a progression of renal failure and atherosclerosis. Despite intensive research, the etiopathogenesis of hypercholesterolemia in CRF patients is still obscure. The present sudy was designed to evaluate the possible role of cholsterol overproduction in the development of hypercholesterolemia associated with experimental CRF. We found that plasma total cholesterol and cholesterol distributed in VLDL, LDL and HDL concentrations were significantly enhanced in CRF rats. Simultaneously, the rate of liver cholesterol biosynthesis in vivo (measured by determining the incorporation of tritium from tritiated water intraperiotoneally injected into cholesterol), liver microsomal 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase activity and liver HMG-CoA reductase mRNA presence were elevated. Significant increases in activity of liver malic enzyme, glucose 6-phosphate dehydrogenase and 6-phosphogluconate dehydrogenase NADPH-producing enzyme (required for cholesterol synthesis) have also been observed in CRF rats. In conclusion, the increased rate of liver cholesterol biosynthesis due to increase of HMG-CoA reductase and NADPH-producing enzyme gene expression could be one of the possible causes of hypercholesterolemia in CRF animals.
2/2
Tytuł oryginału:
Upregulation of fatty acid synthase gene expression in experimental chronic renal failure.
Autorzy:
Szołkiewicz
Marek,
Niewęgłowski
Tomasz,
Korczyńska
Justyna,
Sucajtys
Elżbieta,
Stelmańska
Ewa,
Goyke
Elżbieta,
Świerczyński
Julian,
Rutkowski
Bolesław
Źródło:
Metabolism 2002: 51 (12) s.1605-1610, il., tab., bibliogr. 36 poz.
Sygnatura GBL:
303,583
Hasła klasyfikacyjne GBL:
genetyka
nefrologia
Typ dokumentu:
praca doświadczalna
praca opublikowana za granicą
tytuł obcojęzyczny
Wskaźnik treści:
zwierzęta
szczury
płeć męska
Streszczenie angielskie:
Hypertriglyceridemia associated with chronic renal failure (CRF) and elevated plasma concentration of very-low-density lipoprotein (VLDL) are thought to be a consequence of the depressed lipoprotein lipase and hepatic lipase activities and impaired clearance of lipoproteins. However, ther is some evidence that the lipoproteins overproduction might also contribute to hypertriglyceridemia in CRF. This study was performed to test the hypothesis that the increased rate of lipogenesis consequent to upregulation of fatty acid synthase (FAS), a key lipogenic enzyme, gene expression could contribute to overproduction of triacylglycerols and to hypertriglyceridemia in CRF. FAS activity, FAS protein mass (Western nlot analysis), and FAS mRNA level (Northern blot analysis) in liver and epididymal white adipose tissue (WAT) were measured in male Wistar rats 6 weeks after subtotal (5 of 6) nephrectomy or shan operation. Moreover, the rate of lipogenesis in WAT was determined. The CRF group showed significant increase in FAS gene expression (measured as activity, mRNA, and protein abudance) in both liver and WAT. This was associated with the increase in the lipogenesis rate and with the increase in plasma triacylglycerol and VLDL concentrations. Our results suggest that not only decreased removal, but also an increase of triacylglycerol production could contribute, in part, to the CRF-associated hyperlipidemia. Upregulation of FAS gene expression, shown in this report for the first time, reveals another factor involved in disturbed lipid metabolism in CRF....
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