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Tytuł oryginału: Soluble cytokine receptors in renal vasculitis and lupus nephritis.
Autorzy: Tesar Vladimir, Jirsa jr Milan, Zima Tomas, Kalousova Marta, Bartunkova Jirina, Stejskalova Alena, Dostal Ctibor, Zabka Jiri
Źródło: Med. Sci. Monitor 2002: 8 (1) s.BR24-BR29, tab., bibliogr. 49 poz.
Sygnatura GBL: 313,278

Hasła klasyfikacyjne GBL:
  • immunologia
  • nefrologia

    Typ dokumentu:
  • praca kliniczna
  • badanie porównawcze
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.

    Streszczenie angielskie: Background: The activation of various cytokines, e.g. TNFŕ, IL-1 and/or IL-6, may play an important role in the pathogenesis of renal vasculitis and lupus nephritis (LN). The systemic effect of these cytokines may be modulated by their circulating soluble receptors. The plasma levels of cytokine receptors may thus also be markers of the activation of these cytokines. Material/Methods: The plasma levels of TNFŕ, its soluble receptor p75 (sTNF-RII), IL-6, and the soluble IL-6 receptor (sIL-6R) were measured using ELISA in 17 patients with ANCA-positive renal vasculitis (12 active - ANCA-A, 7 in remission ANCA-R), 9 patients with active lupus nephritis (LN), and 5 healthy subjects. Results: Patients with LN had increased plasma levels of TNFŕ, sTNF-RII, IL-6 and sIL-6R in comparison with controls. Patients with ANCA-A also had increased plasma levels of TNFŕ, sTNF-RII adn sIL-6R in comparison with controls, but the increases in the plasma level of IL-6 was not statistically significant, due to the large standard deviation. Patients with ANCA-R had increased plasma levels of sTNF-RII in comparison to controls, but the plasma levels of TNFŕ were significantly lower in ANCA-R than in NANCA-A. While the ratio of TNFŕ to sTNF-RII was significantly lower in all groups of patients than in the acontrols, the ratio of IL-6 to sIL-6R was significantly increased only in LN in comparison to controls. Conclusions: While increased plasma levels of TNFŕ may be a nonspecific marker of the activity of ANCA-positive renal vasculitis and LN...

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