Wynik wyszukiwania w bazie Polska Bibliografia Lekarska GBL
Liczba odnalezionych rekordów:
Przejście do opcji zmiany formatu
Wyświetlenie wyników w wersji do druku
Alteration of 99mTc-DMSA biodistribution in glomerulonephritis.
Nucl. Med. Rev. 2002: 5 (1) s.15-19, il., tab., bibliogr. 26 poz.
Hasła klasyfikacyjne GBL:
Background: The aim of this study was to assess the relation between 99mTc-DMSA biodistribution and its reliability as a marker of renal function in patients with glomerular kidney diseases. Material and methods: Sixty-seven patients involved in this study were classified into two group saccording to 99mTc-DTPA clearance and serum creatinine values: the 1st group consisted of 42 patients without renal failure while the 2nd group included 25 patients with renal failure. 99mTc-DMSA biodistribution was determined by measuring kidney, blood and urine activity at 2 h and 4 h. Results: The results, compared with those of 23 healhty volunteers, indicated the quantitative alteration of 99mTc-DMSA distribution in both glomerulonephritis patient groups. In reference to the control mean values of 2 h and 4 h, in patients without renal failure, kidney activity was found decreased to 52 p.c. and 57 p.c., while the blood activity increase of 37 p.c. and 44 p.c. was recorded together with the urine activity increase of 38 p.c. and 23 p.c. In patients with renal failure the alterations of renal and blood activity were more remarkable, but the urine loss was found to be unchanged. Conclusions: It is suggested that these biodistribution changes originate mainly from tubular impairment. However, in glomerulonephritis patients, altered glomerula filtration might considerably affect biodistribution of this radiopharmaceutical and limits its suitability for precise quantitative estimation of renal function.
Clinical and bacteriological results from the administration of Cefepime (Maxipime) in patients with severe sepsis.
Med. Sci. Monitor 2002: 8 (11) s.PI97-PI102, il., tab., bibliogr. 29 poz.
Hasła klasyfikacyjne GBL:
dorośli 19-44 r.ż.
dorośli 45-64 r.ż.
dorośli = 65 r.ż.
Background: The aim of the present study was to investigate the clinical and bacteriological efficacy of Cefepime administered to critically ill sepsis patients, as well as possible adverse reactions and interactions. Material/methods: 30 patients with severe sepsis of different origin were treated with Cefepime a dosage of 2.0 g bid. Of these patients, 26 survived (86.67 p.c.). The clinical and bacteriological effects of antibiotic administration were recorded at the end of treatment. Results: The treatment outcomes in terms of clinical results were as follows: 17 patients cured (56.67 p.c.), 7 improved (23.33 p.c.), 2 with unsatisfacotry outcome (6.67 p.c.), and 4 failures (13.33 p.c.). Cefepime treatment resulted in a reduction of the APACHE II score from ca. 20 at the beginning to 9.44 at the end, while the SOFA score fell from 7 to 2.62. This indicates improved clinical status and reversal of multiple organ failure. The bacteriological results were as follows: pathogen eradication in 17 cases (56.6 p.c.), pathogen persistence in 8 cases (26.67 p.c.), and superinfection in 5 cases (16.66 p.c.) Out of 80 total hemocultuers, 63 proved to be sterile. In two cases in vitro ENterococcus faecium was isolated with antibiotic resistance. Of 81 total cutures of infectious foci 10 showed resistance: 4 Pseudomonas aeruginosa, 4 Acinetobacter baumanii, and 2 Enterococcus faecalis. No side effects of Cefepime administration were recorded. Conclusions: Cefepime adminsitration resulted in low mortality, clincial improvement, minimal resistance, and lack of side effects. Cefepime is an effective drug of first choice for critically ill sepsis patients.
Comparison of calcium, magnesium, potassium and sodium contents of Ginko biloba L. leaves from Hungary.
Porównanie zawartości wapnia, magnezu, potasu i sodu w liściach Ginko biloba L. pochodzących z Węgier.
J. Elem. 2002: 7 (1) s.49-56, il., bibliogr. s. 55, sum.
The aim of our preliminary investigations was to determine the Caý+, Mgý+, Na+, K+ cation contents by ICP, cation rates and the magnesium coefficients (z) of ginkgo leaves (Ginkgo biloba L.). Our studies were carried out on ginkgo leaves collected from male and female trees at different times from two Botanical Gardens in Budapest and from Szeged in Hungary. Our results showed that the magnesium, calcium, sodium and potassium contents were always higher in the male samples than in female ones, ecxept one when the calcium content was lower in the male samples originated from Szeged. We have detected the highest ptoassium content in the Szeged samples because of salting for preventing icing in the town. We have found that the magnesium content of leaves was high and increased in the same way during the experimental time independently of the growing sites and the sexes of trees (in May about 3000 ćg/g and in September 5000-6000 ćg/g). The magnesium coefficients were increased from May to September, in May were around 0,08 and in September from 0,08 to 0,14. According to "z" coefficients the Ginkgo biloba trees are not a magnesium sensitive plants but we have fund more information about the plant using as therapeutic agent in modern pharmacology.
Saline containing phosphatidylcholine liposomes possess the ability to restore endothelial function damaged resulting from g-irradiation.
J. Physiol. Pharmacol. 2002: 53 (4 p. 1) s.701-712, il., bibliogr. 19 poz.
Hasła klasyfikacyjne GBL:
The protective action of passive saline filled ("empty") phosphatidylcholine liposomes (PCL) omn endothelial function was examined in thoracic aortas obtained from gamma irradiated (6 Gy) Chinchilla rabbits, and then verified in experiments on non-anesthetized and anesthetized rats. Acetylcholine (ACh)-induced vascular relaxant responses in isolated vascular tissues rats were used as the test of endothelial integrity and its functional ability. It was shown that when added to the bath solution (100 ćg/ml), PCL effectively restored endothelium -dependent ACh relaxations of isolated vascular rings damaged resulting from g-irradiation but had no effect on endothelium-independent vascular responses to therapeutic nitric oxide (NO) donors. The liposomes were also without protective effect when injected to the rabbits intraperitoneally (30 mg/kg) 1 hour before irradiation. In contrast, PCL, being injected at the same dose 1 hour after radiation impact, promote normalization of both endothelium -dependent vascular responses to ACh and nitric oxide (NO) donors. PCL restored also the senitivity of vascular tissues to authentic NO (aqueous NO solution) that was surprisingly increased after irradiation, and normalized relationship between ACh-stimulated NO release and relaxant responseamplitudes in irradiated aortas. Experiments on non-anesthetized and anesthetized rats demonstrated that irradiation led to significant elevation in the level of arterial blood pressure without any changes in cardiac contractility....
z abstraktem i deskryptorami