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Tytuł oryginału: Reactivity of human serum transferrin with two mannose-binding lectins: LCA and ConA.
Autorzy: Sobiesiak Małgorzata
Źródło: Centr. Eur. J. Immunol. 2002: 27 (2) s.63-68, il., tab., bibliogr. 21 poz.
Sygnatura GBL: 313,243

Hasła klasyfikacyjne GBL:
  • immunologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: Acute phase response is a systemic response to mechanical injuries, traumas or bacterial inflammations. Acute phase proteins (apps) play an important role in this non-specific reaction. These serum N-glycoproteins physiologically occur in few variants what is called a microheterogeneity. During acute N-glycoproteins physiologically occur in few variants what is called a microheterogeneity. During acute phase response both concentrations and percentage contents of individual variants are changed. In this report we tried to analyse transferrin microheterogeneity using two lectins: ConcanavalinA (ConA), a lectin from Canavalia ensiformis and for the very first time Lens culinaris agglutinin (LCA). Both lectins have the same specificity for D-glucosyl and D-mannosyl residues. We compared Tf microheterogeneity in three groups of sera: healthy controls and of patients with acute and chronic conditions. To estimate the microheterogeneity of the transferrrin the affinity immunoelectrophoresis according to Bog-Hansen was used. To measure the total transferrin concentration the rocket immunoelectrophoresis acc. to Laurell was used. In a crossed affinoimmunoelectrophoresis with ConA, Tf in healthy sera of patients with traumas and chronic inflammations create four variants: T1, T2, T3, T4 (from the fastest to the most retarded one). The percentage contents in reaction with controls was T1 = 4 p.c., T2 = 9 p.c., T3 = 82 p.c., T4 = 4 p.c. In a crossed affinoimmunoelectrophoresis with LCA, Tf in healthy sera of patients with traumas create three glycoforms: ...

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