Wynik wyszukiwania w bazie Polska Bibliografia Lekarska GBL

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Tytuł oryginału: Neuropharmacology
Tytuł angielski: Synergistic effect of uncompetitive NMDA receptor antagonists and antidepressant drugs in the forced swimming test in rats.
Autorzy: Rogóż Zofia, Skuza Grażyna, Maj Jerzy, Danysz Wojciech
Źródło: Neuropharmacology 2002: 42 (8) s.1024-1030, il., bibliogr. s. 1029-1030
Sygnatura GBL: 305,141

Hasła klasyfikacyjne GBL:
  • psychiatria i psychologia
  • farmacja
  • neurologia

    Typ dokumentu:
  • praca doświadczalna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • zwierzęta
  • szczury

    Streszczenie angielskie: In spite of intensive research, the problem of treating antidepressant-resistant depressive patients has not yet been solved. The authors previously reported that combined administration of imipramine and ther uncomperative NMDA receptor antagonist amantadine reduced immobility time in the swimming test in rats to a much greater extent than treatment alone. The present paper investigates the possibility of synergistic interactions between there antidepressants (imipramine, venlafaxine, fluoxetine) with three uncompetitive NMDA receptor antagonists (imatadine, memantine and neramexane). Most combinations resulted in synergistic (hyperadditive) antidepressive-like effects in the forced swim test. Most interesing was the observation that fluoxetine, which was inactive when given alone, showed a positive effect when combined with amantadine (10 and 20 mg/kg), memantine (2.5 and 5 mg/kg) or neramexane (2.5 and 5 mg/kg). The specificyty of these observations is supported by control open field studies, which demonstrated no significant increase, or even a decrease in general locomotion after coadministration of the compounds. The present results suggest that the combination of traditional antidepressant drugs and NMDA receptor antagonists may produce enhanced antidepressive effects, and this is of particular relevance for antidepressant-resistant patients.

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    Tytuł oryginału: Effect of repeated treatment with reboxetine on the central ŕ1-adrenergic and dopaminergic receptors.
    Autorzy: Rogóż Zofia, Margas Wojciech, Skuza Grażyna, Solich Joanna, Kuśmider Maciej, Dziedzicka-Wasylewska Marta
    Źródło: Pol. J. Pharmacol. 2002: 54 (6) s.593-603, il., tab., bibliogr. 48 poz.
    Sygnatura GBL: 313,156

    Hasła klasyfikacyjne GBL:
  • farmacja

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • szczury
  • płeć męska

    Streszczenie angielskie: Reboxetine (REB) is a member of a new class of antidepressants drugs, which selectively inhibit the neuronal reuptake of noradrenaline. It is devoid of any affinity for neurotransmitter receptors nor does it inhibit monoamine oxidases A or B. Since our earlier studies have shown that antidepressant drugs administered repeatedly increase the responsiveness of ŕ1-adrenergic receptors and induce the up-regulation of postsynaptic dopamine D2/D3 receptors in the rat brain, we designed the present experiments to determine whether repeated administration of REB evokes similar effects. The experiments were carried out on male Wistar rats. REB was administered at a dose of 10 mg/kg (or 30 mg/kg in some cases) once or repeatedly (twice daily for 14 days). The obtained results show that REB administered repeatedly increased exploratory behavior induced by phenylephrine and potentiated the hyperlocomotion induced by D-amphetamine. These behavioral effects indicate the hyperresponsiveness of 1-adrenergic receptors. Biochemical studies did not show any changes in the binding parameters of [3H]prazosin (Bmax or Kd), but the ability of the ŕ1-adrenergic receptor agonist, phenylephrine, to complete for these sites was significantly increased upon repeated administration of REB. Locomotor activity induced by quinpirole was not changed, although there was a potentiation of 7-OH-DPAT-induced locomotor hypereactivity in rats receiving repeated administration of REB. At the same time no significant changes in the binding of [3H]quinpirole and [3H]7-OH-DPAT, or at the level of mRNA...

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    Tytuł oryginału: Effects of combined treatment with selective sigma ligands and amantadine in the forced swimming test in rats.
    Autorzy: Skuza Grażyna, Rogóż Zofia
    Źródło: Pol. J. Pharmacol. 2002: 54 (6) s.699-702, tab., bibliogr. 15 poz.
    Sygnatura GBL: 313,156

    Hasła klasyfikacyjne GBL:
  • psychiatria i psychologia
  • farmacja
  • neurologia

    Typ dokumentu:
  • praca doświadczalna
  • komunikat
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • szczury
  • płeć męska

    Streszczenie angielskie: The obtained results showed that the selective simga 1 receptors agonist, SA4503 (but not siramesine, the sigma 2 receptor agonist), given alone, exerted an antidepressant- like activity in the forced swimming test in rats. Amantadine (an uncompetitive NMDA receptor antagonist) potentiated or revealed the effect of SA4503 or siramesine, respectively, in this model.

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    Tytuł oryginału: Potencjalne działanie przeciwdepresyjne ligandów sigma : rola układu NMDA
    Autorzy: Skuza Grażyna; Polska Akademia Nauk Instytut Farmakologii w Krakowie
    Źródło: - Kraków, IF PAN 2002, 18 s. : tab., bibliogr. 90 poz., 24 cm.
    Seria: Wykłady Monograficzne 63
    Sygnatura GBL: 660,914

    Hasła klasyfikacyjne GBL:
  • psychiatria i psychologia
  • farmacja
  • neurologia

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