Wynik wyszukiwania w bazie Polska Bibliografia Lekarska GBL

Zapytanie: SIWANOWICZ
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Tytuł oryginału: Effects of 5-HT1B receptor ligands microinjected into the accumbal shell or core on the sensitization to cocaine in rats.
Autorzy: Przegaliński Edmund, Siwanowicz Joanna, Papla Iwona, Filip Małgorzata
Źródło: Eur. Neuropsychopharmacol. 2002: 12 (5) s.387-396, il., bibliogr. s. 394-396
Sygnatura GBL: 313,361

Hasła klasyfikacyjne GBL:
  • farmacja
  • neurologia

    Typ dokumentu:
  • praca doświadczalna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • szczury
  • płeć męska

    Streszczenie angielskie: The present study was designed to find out whether 5-HT1B receptors located in subareas of the nucleus accumbens played role in cocaine sensitization in rats, and whether pharmacological activation of these receptors could modify this drug effect. Male Wistar rats implanted bilaterally with cannulae into the accumbens shell or core were microinjected with GR 55562 (an antagonist of 5-HT receptors) or cP 93129 (an agonist of 5-HT1B receptors). The rats, which were repeatedly (for 5 days) administered with cocaine (10 mg/kg) after 5-day withdrawal period, showed significantly higher locomotor hyperactivity in comparison with the observed in saline-pretreated and cocaine challenged rats. GR 55562 (0.1 - 10 ćg/side), administered for 5 days into the accumbens shell, but not into the core, prior to cocaine dose-dependently attenuated cocaine sensitization. When injected for 5 days into either the accumbens shell or core before cocaine, CP 93129 (0.1 - 10 ćg/side) had no effect on the development of cocaine sensitization. To examine the effects of GR 55562 and CP 93129 on the expression of cocaine sensitization, the drugs were given acutely before a challenge dose of cocaine (10 mg/kg) on day 10. No change in cocaine sensitization was observed after injection of GR 55562 (0.1 - 10 ćg/side) to the either accumbens subregion or after injection of CP93129 (0.1-10 ć/side) into the core. However, an intra-accumbens shell injection of CP 93129 (10-30 ćg/side) increased sensitization to cacaine, and this enhancement was attenuated after local injection of GR 55562 (1 ćg/side)...


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    Tytuł oryginału: Effect of some antipsychotic drugs on immunoreactivity in C57BL/6 mice.
    Autorzy: Basta-Kaim Agnieszka, Kubera Marta, Budziszewska Bogusława, Siwanowicz Joanna, Lasoń Władysław
    Źródło: Pol. J. Pharmacol. 2002: 54 (6) s.737-742, il., bibliogr. 24 poz.
    Sygnatura GBL: 313,156

    Hasła klasyfikacyjne GBL:
  • immunologia
  • farmacja

    Typ dokumentu:
  • praca doświadczalna
  • komunikat
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • myszy
  • in vitro

    Streszczenie angielskie: The study examined the effect of some typical and atypical antipsychotic drugs on mouse lymphocyte metabolic and proliferative activity in vitro. The typical antipsychotic drug chlorpromazine (3 x 10**-6, 10**-5 and 10**-4M), significantly inhibited 3H-thymidine incorporation into C57BL/6 mouse spleen cells stimulated by concanavalin A (ConA), lipopolisaccharide (LPS) or pokeweed mitogen (PWM). Chlorpromazine at concentrations of 10**-5 and 10**4 M also suppressed the metabolic activity of splenocytes after ConA stimulation. The atypical antipsychotic agent clozapine (10**-4 and 10**-5 M) decreased the proliferative activity of spenocytes after LPS stimulation, but its inhibitory effect after ConA was observed only at higher concentrations. On the other hand, clozapine did not affect the metabolic activity of splenocytes. Sulpride, a selective dopamine D2 antagonist, at concentrations ranging from 10**-8 to 10**-4 M had no inhibitory effect on the proliferative or metabolic activity of the tested cells. The obtained results indicate that of the three antipsychotic drugs studied, chlorpromazine shows the most potent immunosuppressive effect, clozapine produces a moderate effect and sulpride is totally inactive. These findings suggest that the choice of antipsychotic drugs should also depend on disturbance of immune system activity, in particular those occurring in the several forms of psychosis.

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