Wynik wyszukiwania w bazie Polska Bibliografia Lekarska GBL

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Tytuł oryginału: Long-term results of surgery for early gastric cancer.
Autorzy: Popiela T., Kulig J., Kołodziejczyk P., Sierzega M.
Źródło: Br. J. Surg. 2002: 89 (8) s.1035-1042, il., tab., bibliogr. 47 poz.
Sygnatura GBL: 310,131

Hasła klasyfikacyjne GBL:
  • chirurgia
  • onkologia
  • gastroenterologia

    Typ dokumentu:
  • praca kliniczna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 45-64 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: Bacground: Gastrectomy for early gastric cancer, is widely accepted as an adequate therapeutic method. Recent developments of less invasive procedures require the identification who will benefit from such an approach. Methods: A retrospective study was undertaken of 238 patients with early gastric cancer who underwent gastrectomy from 1977 to 1999. Clinicopathological data relating to survival were evaluated. Results: Analysis of 33 node-positive patients (14 per cent) revealed a tumour diameter greater than 20 mm (P = 0.011), depressed macroscopic type (P 0.05), diffuse histological type (P 0.001), poor tumour differentiation ( P 0.001) and infiltration of the submucosal layer (P 0.002) as factors assopciated with lymph node metastasis. Multivariate analysis found diffuse histological type to be an independent risk factor. The overall 5-year survival rate was 87 p.c., and was significantly better in patients who underwent radical lymphadenectomy than in those who had regional lymph node dissection (92 versus 78 p.c.; P 0.01). Similarly, patients younger than 65 years had a more favourable 5-year survival rate (90 p.c.) than oder ones (77 p.c.). Multivariate analysis with the Cox proportional hazards model confirmed patient age and type of lymphadenectomy as independent prognostic factors. Conclusion: The findings suggest that extended lymph node dissection may be beneficial for some patients with early cancer, althoug randomized clinical trials are needed to evaluate this observation further.

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