Wynik wyszukiwania w bazie Polska Bibliografia Lekarska GBL

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Tytuł oryginału: Stężenie VEGF (vascular endothelial growth factor) w surowicy oraz w płynach opłucnowych u chorych z nowotworową lub gruźliczą patologią opłucnej.
Tytuł angielski: The concentrations of VEGF (vascular endothelial factor) in serum and pleural fluid in patients with pleural malignancy and pleural tuberculosis.
Autorzy: Ziora Dariusz, Sielska-Spytek Ewa, Dworniczak Szymon, Oklek Kazimierz, Kozielski Jerzy
Źródło: Pneumonol. Alergol. Pol. 2002: 70 (9/10) s.458-467, tab., bibliogr. 30 poz., sum.
Sygnatura GBL: 301,096

Hasła klasyfikacyjne GBL:
  • pulmonologia
  • onkologia

    Typ dokumentu:
  • praca kliniczna

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: The purpose of this study was copmarison of VEGF (vascular endothelial growth factor) levels in serum and pleural fluid and estimation of this test usefulness in diagnosis of pleural effusions. VEGF levels were measured by ELISA method in 68 patients (45 males and 23 females) aged 19-81 years. By Light's criteria in 16 cases transudate and in 52 cases exsudate was recognized. By means of fluid cytology, pleural biopsy, microbiology or thoracoscopy in 10 cases pleural metastases from distant organs, in 15 cases coexisting pulmonary neoplasm, in 11 cases mesothelioma and in 16 cases tuberculosis were determined as a cause of fluid accumulation in pleural space. The mean VEGF levels were significantly higer (p 0,001) in patients with exsudates than in patients with transudates (3833 pg/ml and 325 pg/ml respectively). Based on likelihood ratios analysis, as a cut off value in differentiation of exsudates and transudates a value 700 pg/ml was accepted. The sensitivity of this test was 75 p.c. and the specifity 93 p.c. and likelihood ratio (LR) 12,5. The mean VEGF level in exsudates was seven times higher than mean VEGF level in serum (3833 pg/ml and 573 pg/ml respectively). Mean VEGF levels in malignant exsudates (4615 pg/ml) were significantly higher than in tuberculous exsudates (2073 pg/ml). As a cut off value in differentiation between malignant and tuberculous exsudates a value of 4500 pg/ml was accepted. We conclude that our results suggests teh local VEGF production in pleural cavity and the significant role of this cytokine in pleural exsudates accumulations...

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