Wynik wyszukiwania w bazie Polska Bibliografia Lekarska GBL
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SIŃCZAK
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Tytuł oryginału:
Microsatellite instability and gastrointestinal carcinoma: a never-ending story.
Autorzy:
Stachura
Jerzy,
Popiela
Tadeusz,
Czopek
Jacek,
Zazula
Monika,
Rudzki
Zbigniew,
Okoń
Krzysztof,
Kulig
Jan,
Białas
Magdalena,
Kołodziejczyk
Piotr,
Sińczak
Anna,
Papla
Bolesław
Źródło:
Prz. Epidemiol. 2002: 56 supl.: Conference on molecular epidemiology in preventive medicine - achievements and new challenges s.83-93, il., bibliogr. 39 poz. - Konferencja pt. Molekularna epidemiologia w medycynie prewencyjnej - osiągnięcia i nowe wyzwania Kraków 20-22.06. 2002
Sygnatura GBL:
301,250
Hasła klasyfikacyjne GBL:
genetyka
gastroenterologia
onkologia
Typ dokumentu:
praca związana ze zjazdem
tytuł obcojęzyczny
Wskaźnik treści:
ludzie
Streszczenie angielskie:
We briefly review the current status of the research on the microsatellite status of colorectal and gastric carcinomas basing on the literature and our own studies. Investigation of microsatellite instability (MSI) is possible in archival material, and may by applied to analysis of relatively large retrospective series of cases. A specific profile of MSI-H (high) colorectal carcinomas, including right-sided location, mucinous an dsolid histology, and predominance of high-grade cases is a constant finding regardless of the geographical origin of the studied population, despide the fact that other aspects of colorectal cancer pathology differ markedly among various ethnic groups. The MSI-H tumors present several several intuively associated with bad prognosis, including the highest Ki67 proliferative fraction, but paradoxically may be associated with a more favorable outcome than MSS (stable) or MSI-L (low) cancers. The distinct status of the MSI-L colorectal cancers ("mild mutator pathway") is still unclear, but some reports, including our study, suggest that this group may present specific biologic features not necessarily placing it among MSS and MSI-H tumors. In gastric carcinoma the better prognosis linked to the MSI status emerges more and more firmly from the plethora of conflicting data. MSI-L gastric carcinomas may contain disproportionally high percentage of EBV-positive cases. The comparative aspect of the microsatellite research suffers from lack of widely acccepted standardized procedures aimed at detection of MSI, and from inconsistency in defining the MSS, MSI-L and MSI-H phenotypes among various authors.
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Tytuł oryginału:
EBV-positive lymphoepithelial carcinoma of salivary gland in a woman of anon-endemic area - a case report.
Autorzy:
Białas
Magdalena,
Sińczak
Anna,
Choińska-Stefańska
Agnieszka,
Zygulska
Aneta
Źródło:
Pol. J. Pathol. 2002: 53 (4) s.235-238, il., bibliogr. 18 poz.
Sygnatura GBL:
301,852
Hasła klasyfikacyjne GBL:
stomatologia
genetyka
mikrobiologia
onkologia
Typ dokumentu:
praca kazuistyczna
tytuł obcojęzyczny
Wskaźnik treści:
ludzie
dorośli = 65 r.ż.
płeć żeńska
Streszczenie angielskie:
Lymphoepithelial carcinoma of the salivary glands is a very rare malignancy comprising not more than 0.4 p.c. of all salivary gland neoplasms in the non-endemic areas. In contrast it is much more frequent among native Greenlanders, North American Inuit (Eskimo) and Southern Chinese people living in Hong Kong. We report a case of a 74-year-old woman of Polish origin diagnosed with a lymphoepithelial carcinoma of the right parotid gland. The neoplastic cells were negative for EBV latent membrane protein (LMP-1), but in situ hybridisation for EBV mRNA (EBER) demonstrated positivity in almost all epithelial cells. No signs of EBV infection were found in the reactive lymphocytic component. The patient was treated with radiotherapy.
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