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Tytuł oryginału: Does schistosomiasis interfere with application of the Knodell score for assessment of chronic hepatitis C?
Autorzy: Shiha Gamal, Zalata Khaled R.
Źródło: Med. Sci. Monitor 2002: 8 (2) s.CR72-CR77, il., tab., bibliogr. 27 poz.
Sygnatura GBL: 313,278

Hasła klasyfikacyjne GBL:
  • mikrobiologia
  • gastroenterologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: Background: Schistosoma mansoni (SM) is a significant cause of liver disease in many countries. Chronic hepatitis C (HCV) is a worldwide health problem. The association of SM and chronic HCV is not uncommon, especially in areas where both diseases occur. The possible synergistic relationship between them is controversial. Also, the degree of necroinflammatory injury and the state of fibrosis in patients with mixed schistosomias and chronic HCV remains unclear. Material/Methods: 185 individuals were studied: 25 with pure SM, 100 with pure HCV, and 60 mixed HCV and SM (HCV + S), selected from 222 biopsied patients with chronic liver disease treated at the liver unit of the Internal Medicine Department, Mansoura University (July 1999 - May 2000). They were subjected to rectal snip and serological test for schistosomiasis, liver functions, HBV, HCV serological markers, serum qualitative PCR, and liver biopsy. Masson trichrome stain was performed to assess fibrosis. Immuohistochemical staining was performed for HBsAg and HBcAg. The Modified Knodell score was applied to assess the biopsy.

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