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Tytuł oryginału: Influence of losartan and enalapril on urinary excretion of 8-isoprostane in experimental nephrotic syndrome.
Autorzy: Tesar Vladimir, Zima Tomas, Jirsa jr Milan, Crkovska Jirina, Stipek Stanislav, Vernerova Zdena, Serakova Marketa
Źródło: Med. Sci. Monitor 2002: 8 (2) s.BR69-BR74, il., tab., bibliogr. 31 poz.
Sygnatura GBL: 313,278

Hasła klasyfikacyjne GBL:
  • farmacja
  • nefrologia

    Typ dokumentu:
  • badanie porównawcze
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • szczury
  • płeć żeńska

    Streszczenie angielskie: Background: The increased permeability of the glomerular capillary wall in adriamycin nephropathy may be mediated by incrased generation of free radicals, possibility also by the non-enzymatic production of isoprostanes induced by oxidative stress. ACE inhiitors and angiotensin II antagonists may reduce proteinuria, perhaps by decreasing intraglomerular pressure and increasing the selective permeability of the glomerular capillary wall. Material/Methods: We compared the effect of an ACE inhibitor, enalapril, and an angiotensin II atagonist, losartan, on total malodialdehyde in blood and the urinary excretion of certain eicosanodids and their metabolites (TxB2, 6-keto-PGF1a, bicyclo-PGE2 and 8-isoprostane) in experimental adriamycin-induced nephrotic syndrome in rats. Results: Increased proteinuria in adriamycin-treated rats was not prevented by losartan, but tended to be partly mitigated by enalapril. However, both losartan and enalapril prevented the adriamycin-induced increase of total MDA in serum, but urinary excretion of 8-isoprostane was increased in nephrotic rats treated by losartan compared to controls. The enalapril-induced increase in urinary excretion of bicyclo-PGE2 was possibly mediated by kinins. Proteiuria positively correlated with urinary excretion of 8-isoprostane, and proteinuric rats also had a significantly higher urinary excretion of 8-isoprostane than non-proteinuric rats. Conclusions: Proteinuria in the acute phase of adriamycine nephropathy may be dependent on free radical generation and the formation of 8-isoprostane. The mild anitproteinuric effect of enalapril, but not losartan, may suggest the contributory role of the inhibiton of kinin degradation in the antiproteinuric action of enalapril in this model of nephrotic syndrome.

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