Wynik wyszukiwania w bazie Polska Bibliografia Lekarska GBL
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SENYAYLA
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Tytuł oryginału:
Some drug effects on the activity of erythrocyte hexokinase and glucose 6-phosphate dehydrogenase enzymes in vitro and in vivo.
Autorzy:
Ciftci
Mehmet,
Senyayla
Faruk,
zdemir
Hasan,
Bykokuroglu
Mehmet E.
Źródło:
Pol. J. Pharmacol. 2002: 54 (6) s.673-679, il., tab., bibliogr. 20 poz.
Sygnatura GBL:
313,156
Hasła klasyfikacyjne GBL:
farmacja
Typ dokumentu:
praca doświadczalna
tytuł obcojęzyczny
Wskaźnik treści:
ludzie
zwierzęta
szczury
in vitro
Streszczenie angielskie:
Effects of theophyline, lidocaine, cyclophosphamide, hyoscine N-butyl bromide, tranexamid acid and cytarabine on hexokinase (HK) from human erythrocytes have been investigated in vitro. In addition, in vivo effects of theophylline and lidocaine were investigated in rats. HK was purified from human red blood cells by DEAE-Sephadex A50 ion exchange chromatography. HK activity was measured spectrophotometrically at 25řC in a system coupled with glucose 6-phosphate dehydrogenase, according to Beutler's method at 340 nm. Cyclophosphamide, hyoscine N-butyl bromide, tranexamic acid and cytarabine had no effects on human erythrocyte HK activity in in vitro conditions. On the other hand, human erythrocyte HK was inhibited by theophyline, but activated by lidocaine. IC 50 value for theophylline was 0.013 M. In the case of in vivo studies, 6 mg kg-1 of theophylline inhibited the rat HK activity by 43 p.c. at the first 1.5 h (p 0.001). A dose of 5 mg kg-1 of lidocaine activated the rat HK activity by 41 p.c. (p 0.001), 22 p.c. (p 0.001), and 11 p.c. (p 0.05), at 1.5, 3 and 6 h respectively.
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