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Tytuł oryginału: Influence of the stimulation of carotid body chemoreceptors on the gastric mucosal blood flow in artificially ventilated and spontaneously breathing rats.
Autorzy: Siński M., Kowalczyk P., Stolarczyk A., Sawionek Ł., Przybylski J.
Źródło: J. Physiol. Pharmacol. 2002: 53 (3) s.359-369, il., tab., bibliogr. 25 poz.
Sygnatura GBL: 302,092

Hasła klasyfikacyjne GBL:
  • gastroenterologia
  • pulmonologia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca doświadczalna

    Wskaźnik treści:
  • zwierzęta
  • szczury
  • płeć męska

    Streszczenie angielskie: The cardiovascular effects of the stimulation of arterial chemoreceptors are different in spontaneously breathing and artificially ventilated animals. Respiratory failure and long term sojourn a high altitude coincide frequently of gastric ulceration. In both these situations a profound stimulation of arterial chemoreceptors is present. The purpose of the paper was to investigate the reflex effect of stimulation caroid chemoreceptors on gastric mucosal blood flow in the rat. Arterial chemoreceptors were stimulated by two methods (I) substitution gas mixture of 10 p.c. oxygen in nitrogen for room air and (II) direct injection of acid saline (0,05 ml, pH + 6.8) into the distal part of left common carotid artery. In artificially ventilated rats stimulation of arterial chemoreceptors caused significant increase in gastric mucosal vascular resistance, accompanied by marked decline in blood flow. This effect was mediated by adrenergic mechanism. On the contrary to artificially ventilated rats, decline of gastric mucosal vascular resistance with concomitant increase in blood flow was in spontaneously breathing animals. This effect was not abolished either by phentolamine or atropine. As vasodilatatory effect of arterial chemoreceptors stimulation was abolished by bilateral vagotomy, we postulate that non adrenergic and non cholinergic vagal fibers mediate observed vascular changes in gastric mucosa in spontaneously breating rats. We hypothesize that in artificially ventilated patients with respiratory failure stimulation of ...

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