Wynik wyszukiwania w bazie Polska Bibliografia Lekarska GBL

Zapytanie: SANCHEZ
Liczba odnalezionych rekordów: 3



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Tytuł oryginału: The TCR/CD3 complex: molecular interactions in a changing structure.
Autorzy: Feito Maria Jos‚, Jim‚nez-Perianez Arturo, Ojeda Gloria, Sanchez Alejandra, Portol‚s Pilar, Rojo Jos‚ M.
Źródło: Arch. Immunol. Ther. Exp. 2002: 50 (4) s.263-272, il., bibliogr. 94 poz.
Sygnatura GBL: 304,223

Hasła klasyfikacyjne GBL:
  • immunologia

    Typ dokumentu:
  • tytuł obcojęzyczny

    Streszczenie angielskie: The T cell receptor-CD3 (TCR/CD3) complex is a multichain structure in charge of antigen recognition in T cells. Despite many genetic, structural, and functional data obtained in recent years, essential questions concerning the TCR/CD3 complex still remain open, including: 1) the precise number of polypeptides in each TCR/CD3 complex, their interactions and spatial arrangement, 2) the role(s) of each polypeptide in antigen recognition and/or in receptor signal transmission, and 3) the relationship between the TCR/CD3 complex and other membrane or cytoplasmic molecules involved in downstream signaling. In this work we shall review data concerning some of these issues, proposing a model of the overall structure of the TCR/CD3 complex to explain its known features.

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    Tytuł oryginału: Monte Carlo clinical dosimetry.
    Autorzy: Sanches-Doblado Francisco, Leal Antonio, Perucha Maria, Arrans Rafael, Nunez Luis, Rosello Joan V., Sanchez-Nieto Beatriz, Carrasco Ester, Gonzales Antonio, Medrano Juan C., Errazquin Luis, Sanchez-Calzado Jose A.
    Źródło: Rep. Pract. Oncol. Radiother. 2002: 7 (2) s.43-51, il., bibliogr. 20 poz.
    Sygnatura GBL: 313,406

    Hasła klasyfikacyjne GBL:
  • radiologia

    Typ dokumentu:
  • praca kliniczna
  • praca doświadczalna

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: The choice of the most appropriate strategy for radiotherapy treatment is mainly based on the use of a planning system. With the introduction of new techniques (conformal and/or small fields, asymmetrical and non coplanar beams, true 3D calculation, IMRT) the trustworthiness of the algorithms used is questioned. An alternative verification procedure has become increasingly more necessary to warranty delivery. The reliability of the Monte Carlo method is generally acknowledge. However, its clinical use has not been practical due to the high CPU time required. During the last few years our objective has decreased CPU time by means of a new process distribution technique. This reduction has made it feasible, not only to apply physical dosimetry under special conditions, but also to use it in numerous clinicall cases employing photon and electron conformal fields, in radiosurgery, and IMRT. The procedure carried out is presented. Furthermore, conventional Treatment Planning System calculations are compared with the Monte Carlo simultions.

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    Tytuł oryginału: Reconstructing the cours of HIV-1-associated progressive encephalopathy in children.
    Autorzy: Sanchez-Ramon Silvia, Canto-Nogues Carmen, Munoz-Fernandez M. Angeles
    Źródło: Med. Sci. Monitor 2002: 8 (10) s.RA249-RA252, il., bibliogr. 34 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • pediatria
  • aIDS
  • mikrobiologia
  • neurologia

    Typ dokumentu:
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: The factors that trigger the clinical onset of HIV-1-associated progressive encephalopathy (PE) in children remain unknown. HIV-1 invades the central nervous system (CNS) from the very beginning of infection, but the timeframe for PE development is variable. It has recently ben suggested that incrased traffic into the brain of HIV-1-infected or activated moncytes arising directly from the bone marrow may be the first step to clinical onset of adult HIV encephalopathy. The determining factor for this enhanced recruitment of blood monocytes into the CNS in adults has been postulated to be increased HIV-1 replication. However, children usually exhibit high levels of viral load beginning in the first months of life, even under very aggressive antiretroviral therapy. PE inchildren represents a unique form of CNS involvement of HIV, much more common, early, and devastating for children than for adults, representing in fact an independent cause of mortality. In the light of recent literature on this issue and our own in vitro and in vivo results the possible mechanisms implicated in the pathogenesis of PE are descussed. We propose that CD8+ T-lymphocytes would be teh nexus for all the various aspects of teh disease, namely the loss of control over HIV-1 replication, increased traffic of activated monocytes, the spread of infection to immune sanctuaries and finally the neurological emergence of PE. Possible new biologic markers fo neuropathogenesis are suggested.

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