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Tytuł oryginału: Recombinant Coagulation Factor VIIa for rapid preoperative correction of Warfarin-related coagulopathy in patients with acute subdural hematoma.
Autorzy: Veshchev Igor, Elran Hanoch, Salame Khalil
Źródło: Med. Sci. Monitor 2002: 8 (12) s.CS98-CS100, bibliogr. 12 poz.
Sygnatura GBL: 313,278

Hasła klasyfikacyjne GBL:
  • farmacja
  • hematologia
  • neurologia

    Typ dokumentu:
  • praca kazuistyczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 45-64 r.ż.
  • płeć męska

    Streszczenie angielskie: Background: Intracranial hemorrhage, either spontaneous or traumatic is a well-known and potentially lethal complication of Warfarin treatment. Patients with Warfarin-related intracranial hemorrhage need urgent reversal of anticoagulation that must be especially rapid if surgical intervention is indicated. The traditional treatment with fresh frozen plasma (FFP) and vitamin K often fails to achieve the desired correction of coagulopathy in urgent neurosurgical settings. Case report: In the present case Recombinant Coagulation Factor VIIa (rFVIIa) was used for preoperative reversal of Warfarin-related coagulopathy. The patient was a fifty two years old man, mechanic valve recipient with Warfarin-induced coagulopathy: International Normalization Ratio (INR) of 6.39, who suffered from acute subdural hematoma and needed urgent neurosurgical intervention. He received a single dose of rFVIIa 120 ćg/kg and immediately underwent craniotomy and evacuation of the hematoma. Appropriate hematostasis was achieved durring surgery and coagulation test taken two hours after rFVIIa injection revealed INR of 1.25. The INR remained nromalized for additional 14 hours. To the best of our knowledge, this is the first report on the use of rFVIIa in the preoperative management of Warfarin-induced intracranial hemorrhage. Conclusion: Recombinant Coagulation Factor VII provides rapid correction of coagulation to a level that allows safe neurosurgical intervention without significant delay. This agent is safe and effective; and should be considered for reversal of Warfarin-induced coagulopathy...

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