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Tytuł oryginału: Radioiodine-treatment (RIT) of functional thyroidal autonomy.
Autorzy: Meller Johannes, Sahlmann C. O., Becker Wolfgang
Źródło: Nucl. Med. Rev. 2002: 5 (1) s.1-10, il., tab., bibliogr. 72 poz.
Sygnatura GBL: 313,603

Hasła klasyfikacyjne GBL:
  • endokrynologia
  • radiologia

    Typ dokumentu:
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: Since 1942, therapy with radioiodine (RIT) has gained a major role in the treatment of benign thyroid disorders, notably hyperthyroidism caused by Graves' disease or toxic multinodular goitre (thyroid autonomy). In iodine deficient areas thyroid autonomy accounts for 40-50 p.c. of all cases with hyperthyroidism. RIT has become a cost-effective first-line procedure in autonomy-patients with latent or overt hyperthyroidims, especially in the absence of a large goitre, after thyroid surgery and in elderly patients with latent or overt hyperthyroidims, especially in the absence of a large goitre, after thyroid surgery and in elderly patients with associated conditions who carry a high intra- or perioperative risk. Decisions concerning the definitive treatment of thyroid autonomy should take into account previous episodes of hyperthyroidism, objective parameters of risk stratification in euthyroid patients as well as concomitant diseases and the probability of iodine exposure in the future. In Central Europe the majority of investigators prefer to estimate the therapeutic activity individually by a radioiodine test. TCTUs (global 99m-Tc-pertechnetate thyroid uptake under suppression) - based dose concepts have been proven to be highly effective in the elimination of autonomy and carry a low ( 10 p.c.) risk of postradioiodtherapeutic hypothyriodism. Radioiodine therapy for autonomy has been found to be both effective and safe and without major early or late side effects. The most frequent complication is hypothyroidism requiring lifelong follow-up.

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