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Tytuł oryginału: An analysis of prognostic factors and the five-year survival rate in childhood acute lymphoblastic leukemia.
Autorzy: Karimi Mehran, Yarmohammadi Hooman, Sabri Mohammad R.
Źródło: Med. Sci. Monitor 2002: 8 (12) s.CR792-CR796, tab., bibliogr. 32 poz.
Sygnatura GBL: 313,278

Hasła klasyfikacyjne GBL:
  • pediatria
  • hematologia
  • onkologia

    Typ dokumentu:
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dzieci 2-5 r.ż.
  • dzieci 6-12 r.ż.
  • dzieci 13-18 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: Background: Acute Lymphobastic Leukemia (ALL) is the most common malignancy in childhood. With newer drug protocols the five-year survival rate is now close to 80 p.c. Various factors have been reported to be important for prognosis and should be considered when planning treatment. Material/Methods: In a cross-sectional study, prognostic variables and the five-year survival rate were analyzed. Data regarding demographic characteristics, family and personal history, manifestations at the time of presentation, therapeutic regimens and outcome were collected from the records of 76 ALL patients in the treatment five years prior to the study. Two pathologists performed the staging using the morphology method (L1, L2 and L3). Results: Fifty-five subjects (72.5 p.c.) survived until the end of the study. One subject succumbed to the rapid fatal course of the disease and 20 others passed away due to relapses or infection during follow-up. Conclusion: Among all variables a worse prognosis was associated (p 0.05) wiht WBC counts greater than 50.000/ml at presentation, relapse in the CNS, and relapse in the bone marrow. When Anthracycyline was included in the therapeutic regimen, the effect of chemotherapy was more favorable compared to regimens without Anthracycline (p 0.05). Other variables previously reported to have prognostic value, especially age and sex, were not significantly in our study (p 0.05). Other factors which might account for a poorer included the preponderance of L2 morphology, difficult assess to medical care, decreased compliance of families due...

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