Wynik wyszukiwania w bazie Polska Bibliografia Lekarska GBL

Zapytanie: ROY
Liczba odnalezionych rekordów: 5



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1/5

Tytuł oryginału: Tailoring the initial vascular access for dialysis patients
Autorzy: Konner Klaus, Hulbert-Shearon Tempie E., Roys Erik C., Port Friedrich K.
Źródło: W: 2. Katowickie Seminarium "Postępy w nefrologii i nadciśnieniu tętniczym" : [materiały zjazdowe] - Katowice, [2002] s.[235-244], il., tab., bibliogr. 28 poz. - 2 Katowickie Seminarium pt. Postępy w nefrologii i nadciśnieniu tętniczym Katowice 14-16.11. 2002
Sygnatura GBL: 802,649

Hasła klasyfikacyjne GBL:
  • nefrologia

    Typ dokumentu:
  • praca związana ze zjazdem
  • praca epidemiologiczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • płeć męska
  • płeć żeńska

    2/5

    Tytuł oryginału: Effect of desogestrel on blood-lipid in relation to its biological activities.
    Autorzy: Saha Achintya, Roy Kunal, De Kakali, Sengupta Chandana
    Źródło: Acta Pol. Pharm. 2002: 59 (1) s.65-69, tab., bibliogr. 35 poz.
    Sygnatura GBL: 301,378

    Hasła klasyfikacyjne GBL:
  • farmacja

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta

    Streszczenie angielskie: Desogestrel (DG), a 19-nor progestin, is widely used in replacement therapy as a contraceptive steroidal hormone. Considering the importance of its partition coefficient parameter (log P = 5.68), a significant contributor to its action mechanism, interactions of the drug with blood-lipids, had been investigated using phospholipid binding, fatty acid composition and peroxidation phenomena as the parameters under investigation to explain its pharmacodynamic behavior. From the present investigation, it was observed that lipid loss after incubation of whole blood with DG (80 ng/ml, effective contraceptive concentration in blood) for varying periods of time was accompanied with significant changes in fatty acid composition, which may be ascribed to binding affinity of DG with lipid constituens in blood that may have a role in the mediation of its therapeutic effect. Lipid peroxidation induction potential of DG has been quantitatively measured in the context of its toxicity. The results reveal that DG caused significant extent of lipid peroxidation. Ascorbic acid, an antioxidant, at equvalent human dose of 250 mg could significantly reduce DG-induced lipid peroxidation.

    3/5

    Tytuł oryginału: Intervention in patients with pneumothorax immediately following CT-guided fine needle aspiration of pulmonary nodules.
    Autorzy: Shantaveerappa Harsha N., Mathai Mathew G., Byrd jr Ryland P., Karnad Anand B., Mehta Jayant B., Roy Thomas M.
    Źródło: Med. Sci. Monitor 2002: 8 (6) s.CR401-CR404, tab., bibliogr. 18 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • pulmonologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: The incidence of pneumothorax (PTX) as a complication of computerized tomography guided fine needle aspirates (CT-FNA) of solitary pulmonary nodules (SPN) varies from 8 - 61 p.c. It has been suggested that the practice of obtaining a delayed chest radiograph in patients who have undergone CT-FNA of SPN is not cost effective and adds little information concerning lung expansion obtained by CT and the end of the procedure. It, however, is not known what percent of patients with a PTX present immediately after CT-FNA but do not require prompt chest tube placement will progress and require intervention later. One hundred-fifty-eight consecutive patients undergoing CT-FNA of SPN were included in the study. Immediately after CT-FNA each patient was reimaged with the CT scanner to checka for PTX. Patients with a PTX immediately after CT-FNA were assessed as to whether intervention was undertaken or whether the PTX enlarged and/or required drainage at a later time. Thirty-eight patients developed a PTX while still on the CT scanner. Twenty-nine patients with an immediate PTX did not require drainage of their pleural space. Chest tube placement was required prompty after the CT-FNA in 4 patients. Five patients had their pleural space drained at a later time due to an increasing size of the PTX and/or the development of symptoms attributed to the PTX. These data suggest that patients who develop a PTX immediately after CT-FNA but who do not require prompt pleural space evacuation should be followed closely both clinically and radiographically.

    4/5

    Tytuł oryginału: Mechanism of in vitro release kinetics of flurbiprofen loaded ethylcellulose micropellets.
    Autorzy: Mallick Subrata, Roy Kunal, Chakraborty Atanu, Saha Subhayu
    Źródło: Acta Pol. Pharm. 2002: 59 (3) s.193-198, il., tab., bibliogr. 15 poz.
    Sygnatura GBL: 301,378

    Hasła klasyfikacyjne GBL:
  • farmacja

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • in vitro

    Streszczenie angielskie: Flurbiprofen loaded ethylcellulose micropellets with different drug loading were prepared by a quasi-emulsion solvent diffusion technique. Encapsulation parameters of micropellets such as actual drug loading, drug encapsulation efficiency (DEE) and loss of coating polymer (LCP) were determined. Actual drug loading was increased with the increased initial drug loading whereas encapsulation efficiency decreased with the increase of actual drug loading. In vitro drug release profiles of these micropellets were evaluated in distilled water (DW) and also in phosphate buffer solution (PBS) to indicate pH dependency release rates. All the batches of micropellets released about 35-59 p.c. in DW and 89-97 p.c. in PBS during the period of 8 h and the burst effect of about 50-75 p.c. in the first 1.5 h was seen only in PBS. The mechanism of release kinetics was evaluated by fitting the release data to the zero order, first order. Higuchi, Baker-Lonsdale and Peppas equations and also to the differential forms of zero order, first order and Higuchi model. Adequate fitting of release data was found with first order, Higuchi and Peppas models and hence these models were selected for F-test statistics for ascertaining the mechanism of drug release. Higuchi model of drug release in DW an dPBS of all the formulations was ruled out due to its significantly different F-value with other models. Thus, mechanism of release of flurbiprofen from ethylcellulose micropellets may be explained by the diffusional exponent model of Peppas et al. as ascertained by F-test statistics rather than the same, based on some other diffusional models even though they have shown good correlation.

    5/5

    Tytuł oryginału: Evaluation of probucol as suppressor of ceftizoxime induced lipid peroxidation.
    Autorzy: Roy Kunal, Saha Achintya, De Kakali, Sengupta Chandana
    Źródło: Acta Pol. Pharm. 2002: 59 (3) s.231-234, tab., bibliogr. 34 poz.
    Sygnatura GBL: 301,378

    Hasła klasyfikacyjne GBL:
  • farmacja
  • toksykologia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta

    Streszczenie angielskie: Considering drug induced lipid peroxidation, a possible mediator of drug induced toxicity and exploiting free radical scavenging action of probucol, which is a synthetic antioxidant of therapeutic interest, in vitro effects of the antioxidant on drug induced lipid peroxidation have been studied to explore its possible potential in reducing drug induced toxicity. In the present study, ceftizoxime sodium, a third generation of cephalosporin, has been taken as the representative drug and goat whole blood has been used as the lipid source. The study revealed that probucol could suppress drug induced lipid peroxidation to a significant extent. This provides scope for further study on probucol to evaluate its potential for reducing drug induced toxicity and increasing therapeutic index of drug by possible cotherapy.

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