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Tytuł oryginału: Molecular biology of prions.
Autorzy: Weissmann Charles, Enari Masato, Kl”hn Peter Christian, Rossi Daniela, Flechsig Eckhard
Źródło: Acta Neurobiol. Exp. 2002: 62 (3) s.153-166, il., tab., bibliogr. [111] poz.
Sygnatura GBL: 302,090

Hasła klasyfikacyjne GBL:
  • neurologia
  • genetyka

    Typ dokumentu:
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • zwierzęta

    Streszczenie angielskie: The "protein only" hypothesis holds that the infectious agent causing transmissible spongiform encephalopathies is a conformational isomer of PrP, a host protein predominantly expressed in brain and is strongly supported by many lines of evidence. Prion diseases are so far unique among conformational diseases in they are transmissible, not only experimentally but also by natural routes, mainly by ingestion. The pathway of prions to the brain has been elucidated in outline. A striking feature of prions is their extraordinary resistence to conventional sterilisation procedures, and their capacity to bind to surfaces of metal and plastic without losing infectivity. This property, first observed in a clinical setting, is now being investigated in experimental settings, both in animals in cell culture.


    Tytuł oryginału: Predictors of change in exercise capacity after comprehensive COPD inpatient rehabilitation.
    Autorzy: Cilione Carmela, Lorenzi Cristina, Dell'Orso Daniela, Garuti Giancarlo, Rossi Giuseppina, Totaro Lina, Clini Enrico
    Źródło: Med. Sci. Monitor 2002: 8 (11) s.CR740-CR745, tab., bibliogr. 29 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • pulmonologia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca kliniczna

    Wskaźnik treści:
  • ludzie
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: Background: In order to evaluate the factors associated with change in exercise capacity after comprehensive inpatient Pulmonary Rehabilitation (IPR) we studied 132 consecutive adults with Chronic Obstructive Pulmonary Disease (COPD) recovering from an acute exacerbation. Material/Methods: Lung function, arterial blood gases, and respiratory muscle strength were measured at baseline. Perceived breathlessness (B), 6-minute walk distance (6MWD) dyspnea at rest and postexertion (D), hospital anxiety and depression (HAD), and health-related quality of life were assessed before (T0) and after (T1) IPR. The patients were divided into two groups depending on the change in 6MWD: Improvers (IM at least +54 meters after IPR, n = 81) or Non-Improvers (NIM less htan 54 meters or no change, n = 51). Results: At T1 61 p.c. of the patients showed improvement as here defined. The IM group showed lower 6MWD and higher B and resting-D at T0than NIM (p 0.05). A stepwise multiple regression analysis was performed using 6MWD change as the dependent variable and anthropometric and physiological measures at T0 as the independent variables. This regression model explained 26 p.c. of the 6MWD-change; 6MWD and PaO2 significantly contributed to this model. Conclusions: In COPD patients recovering from an acute exacerbation, the predicted change in exercise capacity using anthropometric, demographic, clinical, and physiological variables after 2 weeks of comprehensive IPR is likely to be low. The baseline level of exercise performance and arterial oxygenation who the most consistent correlation with change in walking ability in these patients.

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